The American Bullfrog (Lithobates catesbeianus) is a large, commonly encountered amphibian. The bullfrog is not considered poisonous to humans in the way that genuinely toxic amphibians are. While it is not harmless, its natural defenses do not involve the potent, life-threatening toxins associated with other species. Understanding its specific physical and biological defenses is important for safely interacting with this widespread creature.
Understanding the Difference Between Poison and Venom
The terms “poisonous” and “venomous” describe how a toxin is delivered and are not interchangeable. An organism is considered venomous if it actively injects a toxin, typically through a bite, sting, or specialized structure. Snakes and scorpions are prime examples of venomous creatures.
In contrast, an organism is designated as poisonous if the toxin is delivered passively, meaning it must be absorbed, inhaled, or ingested to cause harm. This is the primary defense mechanism for most amphibians, which secrete substances from skin glands. These secretions make them poisonous if a predator attempts to consume or lick them. The American Bullfrog lacks the specialized mechanism required to inject venom.
The American Bullfrog’s Natural Defenses
The American Bullfrog primarily relies on its size and intimidation as a first line of defense. If cornered, the frog will inflate its body to appear larger and may let out a loud, startling distress call. This large size and aggressive posture are often enough to deter a potential predator.
The bullfrog does possess skin secretions, common among amphibians, but these are irritating rather than potently toxic. These secretions contain mild irritants, such as mucoproteins, designed to taste bad or cause a slight burning sensation in the mouth of a predator. They serve as a chemical deterrent but do not contain powerful neurotoxins.
The most significant risk to human health comes from bacteria carried on the bullfrog’s skin. Bullfrogs can carry Salmonella bacteria in their digestive tracts and on their skin. Contact can transfer the bacteria, which can lead to salmonellosis, especially if a person touches their mouth or eyes afterward. This bacterial risk is a far greater health concern than any mild skin irritant.
Why Bullfrogs Are Sometimes Mistaken for Dangerous Amphibians
The misconception about the American Bullfrog often stems from confusion with other genuinely toxic amphibian species found in North America and globally.
Highly Toxic Toads
Certain toads, such as the Cane Toad (Rhinella marina), possess specialized parotoid glands that secrete bufotoxin. This powerful cocktail of cardiac glycosides and other compounds can cause severe illness, seizures, and even death in animals that bite or lick them.
Another toxic species is the Colorado River Toad, also known as the Sonoran Desert Toad (Incilius alvarius), found in the southwestern United States and Mexico. This toad secretes a potent poison containing bufotenin and 5-MeO-DMT, which can be psychoactive and deadly if ingested.
The American Bullfrog lacks the large, distinctive parotoid glands and potent bufotoxins that make these other species dangerous. The bullfrog has relatively smooth, green or brownish skin, while poisonous toads have rougher, warty skin and prominent poison glands. Furthermore, highly toxic species are geographically restricted to specific regions, whereas the American Bullfrog is widespread across the continent.
Safe Handling Practices and Risk Assessment
Since the American Bullfrog is not poisonous, the overall risk to humans is low, provided basic hygiene practices are followed. It is best to minimize unnecessary contact with any wild animal that may harbor bacteria. If handling a bullfrog is necessary, do so carefully to avoid stressing the animal or being bitten, as their jaws can exert a strong grip.
The most important safety measure after any contact is thorough handwashing with soap and water. This action mitigates the greatest actual danger posed by the frog: the risk of contracting a Salmonella infection. Children should be supervised and prevented from touching their faces after handling any frog or toad.

