Can I Take Melatonin the Night Before Surgery?

The night before a surgical procedure often brings anticipation and anxiety, making a restful night’s sleep feel impossible. For many struggling to relax, taking an over-the-counter sleep aid like melatonin seems like a harmless solution. Melatonin is a neurohormone naturally produced by the pineal gland that helps regulate the body’s sleep-wake cycle. However, the period preceding surgery involves strict safety protocols, and using any substance requires careful consideration. The decision to take melatonin before an operation depends on its potential to interact with anesthesia and recovery.

Understanding Pre-Surgery Supplement Restrictions

The general rule leading up to surgery is to discontinue the use of most supplements, herbal remedies, and some over-the-counter medications. This mandate exists because non-prescription products can interfere with two fundamental aspects of a safe surgical outcome. The first concern involves interference with the body’s blood clotting mechanisms, as supplements can have anti-platelet properties that increase the risk of excessive bleeding. The second risk is the unpredictable interaction between supplements and the anesthetic agents administered during surgery. Anesthetic drugs are carefully dosed based on a patient’s physiology, and introducing an unapproved supplement can alter how the body metabolizes these agents, potentially affecting the depth of anesthesia or prolonging recovery. Medical teams typically recommend stopping all non-essential supplements one to two weeks before the scheduled operation.

How Melatonin Specifically Affects Anesthesia and Recovery

Melatonin’s function as a sleep regulator poses a direct physiological risk when combined with general anesthesia. The supplement acts as a central nervous system depressant, meaning it can strengthen the sedative effects of anesthetic medications. This additive effect may lead to over-sedation, complicating the precise control needed during the procedure, or causing prolonged post-operative drowsiness. Melatonin also has a mild hypotensive effect, meaning it can slightly lower blood pressure. Since blood pressure, heart rate, and body temperature are meticulously managed by the anesthesiologist, any unmonitored agent influencing these vitals or thermoregulation introduces unnecessary risk.

Official Guidelines and Necessary Consultations

The definitive answer to whether you can take melatonin the night before surgery is to consult your specific medical team. While some surgeons may permit low-dose melatonin, many institutions categorize it as a supplement to be discontinued, often two weeks prior, to eliminate all potential risks. The anesthesiologist must be aware of every substance in your system to correctly calculate medication dosages and provide individualized advice based on your medical history, the type of surgery, and the specific anesthetic plan.

If you have already taken melatonin or any other unapproved supplement the night before or morning of your procedure, you must immediately disclose this to the surgical team upon arrival. Transparency is the single most important factor for safety, as the medical staff can then adjust their plan to mitigate any potential interactions. For those struggling with pre-operative insomnia, it is far safer to discuss non-pharmacological alternatives with your care providers. Techniques like mindful breathing, meditation, or focusing on strict sleep hygiene are safe methods to encourage rest without introducing an unknown variable into your system.