Plasma donation, or plasmapheresis, involves drawing blood, separating the liquid plasma component, and returning the remaining blood cells to the donor. This life-saving product is used to create therapies for various conditions, including immune deficiencies, bleeding disorders, and trauma. Many people who menstruate wonder if their monthly cycle affects their eligibility. Menstruation itself is rarely a direct reason for deferral, but the body’s response to the cycle may sometimes lead to a temporary pause in donation.
Menstruation and Donation Eligibility
The presence of a menstrual cycle is generally not an automatic disqualifier for donating plasma. Eligibility is determined by universal health criteria designed to protect both the donor and the recipient. Requirements focus on factors like being at least 18 years old, weighing a minimum of 110 pounds, and being in good health on the day of donation. The primary concern during a menstrual period is not the cycle itself, but any accompanying physical symptoms or changes in blood composition. Donation staff focus on objective measurements rather than the presence of a period to ensure the donor’s well-being.
Why Hemoglobin Levels Matter
The most common reason a person on their period might be deferred is low hemoglobin levels. Hemoglobin is an iron-rich protein in red blood cells that carries oxygen throughout the body. Since plasma donation involves taking a portion of whole blood, centers must ensure the donor’s hemoglobin is high enough to remain healthy after the procedure. The pre-donation screening involves a finger-prick test to measure the level, which must meet a minimum threshold, typically around 12.5 g/dL for women. Menstrual bleeding causes a temporary loss of iron, which can sometimes drop the level below the required minimum. If the level is too low, the donor is temporarily deferred to prevent symptoms like excessive fatigue or dizziness after the donation. This strict limit is set high to ensure the donor remains safe.
Tips for Donating During Your Period
Preparation can significantly improve the donation experience, especially when menstruating.
Hydration
Maintaining excellent hydration is important, as plasma is primarily water. Being well-hydrated makes the plasmapheresis process easier and minimizes the risk of post-donation lightheadedness. Water intake should be increased in the 24 hours leading up to the appointment.
Nutrition
Eating a meal rich in iron and protein approximately three hours before the donation can also help support healthy blood levels. Iron is necessary for hemoglobin production, and consuming iron-rich foods helps the body prepare for the minor loss that occurs.
Communication
If a donor is experiencing heavy flow or severe cramping, they should discuss this with the donation staff upon arrival. While these symptoms do not automatically disqualify a person, the staff can provide individualized guidance and ensure comfort during the procedure.

