Rabies is a severe disease that affects the central nervous system of mammals, and the presence of wild animals in residential areas often raises concerns about potential transmission. Opossums, with their nocturnal habits, are frequently encountered by people and are a source of common public inquiry regarding this virus. Understanding the actual risk level associated with these unique marsupials is important for public health awareness and managing interactions with local wildlife. The question of whether an opossum can transmit rabies involves examining both public health data and the animal’s distinct biology.
The Low Risk of Rabies in Opossums
The direct answer to the question of opossums and rabies is that the incidence is exceptionally low compared to other wild mammals. While any mammal is technically susceptible to the Lyssavirus that causes rabies, confirmed cases in opossums are statistically scarce across the United States. Data collected by the Centers for Disease Prevention and Control (CDC) consistently shows that opossums account for less than one percent of all reported rabies cases in wildlife populations.
This low rate positions them far outside the primary reservoir species for the virus in North America. Animals like raccoons, skunks, foxes, and bats are the most common carriers and pose a significantly higher risk of transmission to humans and domestic animals. The observational rarity of rabid opossums has been noted by wildlife experts for decades.
Biological Factors Limiting Rabies Transmission
The biological reason for the opossum’s low susceptibility lies in its unique thermoregulation. The opossum maintains a naturally lower average body temperature than most other placental mammals, typically ranging between 94 and 97 degrees Fahrenheit. This specific temperature range creates a less hospitable internal environment for the rabies virus.
The rabies virus is a heat-sensitive pathogen that thrives and replicates more effectively in warmer body temperatures, such as the 98.6 degrees Fahrenheit common in many other mammalian hosts. The few degrees of difference in the opossum’s core temperature appear to inhibit the virus’s ability to successfully progress through the incubation and replication cycle necessary to reach the central nervous system. This biological resistance means that even if an opossum is bitten by a rabid animal, the infection often fails to develop into the symptomatic, transmissible stage.
Immediate Steps After Wild Animal Contact
Despite the low statistical probability of rabies in an opossum, any direct contact involving a bite, scratch, or exposure to saliva from any wild animal requires immediate action. Thoroughly clean the wound or exposed area with soap and running water for at least 15 minutes. This simple washing can significantly reduce the concentration of viral particles at the site of exposure, helping to prevent infection.
Following immediate wound care, seek professional medical attention at a healthcare facility or emergency department. Medical professionals will assess the specific risk based on the animal involved and the nature of the exposure before deciding if Post-Exposure Prophylaxis (PEP) is necessary. PEP typically involves a series of rabies vaccinations and may include a dose of Human Rabies Immune Globulin (HRIG), which provides immediate antibodies to neutralize the virus.
Never attempt to capture or handle a wild animal yourself, even if it appears sick or injured, as this increases the risk of further exposure. Instead, contact your local animal control or health department to report the incident and allow them to safely manage the animal for potential testing. Timely assessment and intervention are necessary because rabies is nearly always fatal once symptoms appear.

