Tezspire is given as a subcutaneous injection (just under the skin) once every 4 weeks at a fixed dose of 210 mg. You can receive it at a doctor’s office, or you may be able to inject it yourself at home after proper training. The drug comes in a pre-filled syringe or a pre-filled pen, both containing a single dose.
Where to Inject
If you’re self-injecting, your two options are the thigh and the abdomen. When injecting in the abdomen, avoid the 2-inch area around your navel. The upper arm is also an approved site, but only when a healthcare provider or caregiver is giving the injection. You should not self-inject in the upper arm.
Rotate your injection site each time. Pick a spot at least 1 inch away from where you last injected. Avoid any skin that is tender, bruised, red, or hard.
Preparing the Injection
Tezspire is stored in the refrigerator between 36°F and 46°F. Before injecting, take it out and let it warm to room temperature, which typically takes about 60 minutes. Don’t try to speed this up with a microwave or warm water.
If needed, you can keep Tezspire at room temperature (68°F to 77°F) for up to 30 days. Once it’s been stored at room temperature, don’t put it back in the refrigerator. If it hasn’t been used within that 30-day window, discard it.
Self-Injection at Home
Home injection is an option once your healthcare provider determines you (or a caregiver) can handle it safely. Your first injection will typically be given in a clinical setting so you can be observed and trained on proper technique. After that, you can administer it at home on your regular 4-week schedule.
The pre-filled pen is designed to be straightforward: you press it against your skin and activate it, and it delivers the full dose automatically. The pre-filled syringe requires you to manually push the plunger. Both contain the same 210 mg dose, so the choice often comes down to personal comfort and your provider’s recommendation.
If You Miss a Dose
Tezspire works best when taken on a consistent every-4-weeks schedule. If you miss your scheduled injection, take it as soon as you can and then reset your schedule from that new date. Don’t double up on doses.
Disposing of Used Pens and Syringes
After each injection, place the used pen or syringe immediately into an FDA-cleared sharps disposal container. If you don’t have one, a heavy-duty plastic household container with a tight-fitting lid (like a laundry detergent bottle) works as a temporary substitute. Never throw loose needles in the trash, flush them down the toilet, or put them in a recycling bin. Keep sharps containers out of reach of children and pets, and check your local guidelines for drop-off or pickup programs when the container is full.
What Tezspire Treats and How It Works
Tezspire is FDA-approved as an add-on maintenance treatment for two conditions in patients aged 12 and older: severe asthma and inadequately controlled chronic rhinosinusitis with nasal polyps. It is not a rescue medication and won’t help during an active asthma attack.
The drug works by blocking a signaling protein called TSLP that the cells lining your airways release when they sense irritants or damage. TSLP normally kicks off a chain of immune responses that drives airway inflammation. By intercepting TSLP before it can reach its receptor, Tezspire shuts down this inflammatory cascade at its source. This is what makes it different from other biologic asthma treatments that target later steps in the process: Tezspire works upstream, which is why it can be effective across different types of severe asthma regardless of a patient’s specific inflammatory profile.