Dupixent can be out of the fridge for up to 14 days, as long as the temperature stays at or below 77°F (25°C). After 14 days at room temperature, any unused syringes or pens must be thrown away. They cannot be put back in the refrigerator.
The 14-Day Room Temperature Window
Once you remove Dupixent from the refrigerator, a 14-day clock starts. During that window, the medication remains stable and safe to use as long as it stays below 77°F. After day 14, the manufacturer requires you to discard it, even if the syringe or pen looks perfectly normal and hasn’t been opened.
This applies to all forms of Dupixent: the 100 mg syringe, the 200 mg syringe and pen, and the 300 mg syringe and pen. There is no difference in the room temperature time limit between doses or delivery devices.
Temperature and Light Matter
The 77°F ceiling is firm. If your home, car, or travel bag gets warmer than that, the 14-day guideline no longer applies, and the medication may degrade faster. Never heat Dupixent to speed up warming, place it in direct sunlight, or leave it in a hot car.
Light exposure also breaks down the medication over time. Keep your syringes or pens in the original carton whenever they’re not actively being used. The carton blocks light and makes it easy to track the date you took them out of the fridge (writing the date on the box is a simple habit worth building).
Can You Put It Back in the Fridge?
No. Once Dupixent has reached room temperature, it should not be returned to the refrigerator. The labeling is clear: use it within 14 days or discard it. Plan ahead so you only take out what you’ll need within that two-week window.
Warming Before Injection
Cold injections can sting more, so the FDA-approved instructions recommend letting Dupixent warm up on a flat surface before you inject. The wait time depends on the dose:
- 100 mg or 200 mg syringes and pens: at least 30 minutes at room temperature
- 300 mg syringes and pens: at least 45 minutes at room temperature
If your Dupixent has already been stored at room temperature (within the 14-day limit), it’s already warm and ready to inject without an additional waiting period.
Traveling With Dupixent
For short trips of two weeks or less, you can simply carry Dupixent at room temperature in its original carton, tucked into your luggage away from direct sunlight. No cooler bag is needed as long as the ambient temperature stays below 77°F.
For longer trips, or travel to warm climates, you’ll want an insulated cooler bag with ice packs to keep the medication refrigerated. This preserves the full shelf life and avoids triggering the 14-day countdown until you’re ready. Avoid letting ice packs touch the syringes directly, since freezing damages Dupixent just as heat does. If you’re flying, pack Dupixent in your carry-on. Checked luggage can reach extreme temperatures in the cargo hold.
Quick Reference
- Maximum time out of the fridge: 14 days
- Maximum temperature: 77°F (25°C)
- Re-refrigeration: not allowed
- Light protection: keep in original carton
- Freezing: never freeze
- After 14 days at room temperature: discard, even if unused