How Long Do Antibiotics Take to Work for Strep?

Strep throat is a highly contagious bacterial infection caused by Group A Streptococcus (Streptococcus pyogenes), commonly affecting the throat and tonsils. Unlike viral infections that cause sore throats, strep throat requires antibiotic treatment to clear the bacteria, reduce symptom severity, and prevent potential complications. Starting treatment quickly is important to shorten the duration of the illness and minimize the risk of transmission. The timeline for feeling better and no longer being contagious depends directly on when antibiotic therapy begins.

How Quickly Symptoms Improve

Once antibiotic treatment is initiated, most individuals will begin to experience noticeable improvement in their symptoms within 24 to 48 hours. This timeframe represents the period where the medication starts to significantly reduce the bacterial load in the throat, allowing the body to recover. The initial symptom that typically subsides is fever, which often breaks first as the infection comes under control. Following the reduction in fever, a gradual improvement in throat pain and difficulty swallowing occurs. Pain relief medications can be used alongside antibiotics to manage discomfort during this initial phase.

When You Are Safe to Return to School or Work

A person with strep throat is highly contagious until the bacteria causing the infection have been sufficiently suppressed by medication. The standard medical guideline for returning to public settings, like school or work, is to wait until a full 24 hours have passed since the first dose of antibiotics was taken. This 24-hour period is the accepted benchmark for rendering the person non-contagious, significantly reducing the risk of spreading the bacteria to others. Additionally, public health guidance recommends that the individual should be fever-free without the use of fever-reducing medication before returning to normal activities. Replacing your toothbrush 24 to 48 hours after starting antibiotics is also a good practice to prevent reinfection.

The Critical Need to Finish All Medication

Even though symptoms may disappear quickly, it is necessary to complete the entire course of antibiotics as prescribed, which is commonly a 10-day regimen. Stopping the medication early leaves behind the hardiest bacteria that were not killed off. These surviving bacteria can then multiply, leading to a relapse of the infection. Furthermore, incomplete treatment increases the risk of those remaining bacteria developing resistance to the antibiotic, which makes future infections much harder to treat. The primary reason for treating strep throat with a full course of antibiotics is to prevent serious, delayed complications, including rheumatic fever and post-streptococcal glomerulonephritis.

What to Do If Symptoms Persist or Worsen

If the expected improvement timeline is not met and symptoms show no sign of lessening after 48 hours of consistent antibiotic use, contact your healthcare provider. A lack of improvement after two days may suggest that the initial antibiotic is not working effectively, or that the infection is not strep throat. In some cases, the symptoms may be caused by a viral infection, which antibiotics do not treat. A healthcare professional may then decide to retest for the bacteria or switch to a different class of antibiotic to ensure the infection is completely cleared. Persistent or worsening symptoms can also be a sign of a peritonsillar abscess, which requires prompt medical attention.