A cortisone shot, also known as a corticosteroid injection, delivers powerful anti-inflammatory medication directly into a specific area of the body. The medication is a synthetic version of cortisol. The injection works to suppress the localized immune response, reducing swelling, irritation, and pain. These shots are commonly used to manage conditions like arthritis, tendinitis, and bursitis.
Understanding the Typical Timeline of Relief
The pain relief offered by a cortisone injection is not immediate, as the corticosteroid needs time to reduce inflammation effectively. Many injections are mixed with a local anesthetic, which provides a fast-acting numbing sensation that wears off within a few hours. The anti-inflammatory effect of the cortisone typically begins within 24 to 72 hours following the procedure.
Patients may experience a temporary increase in pain, often called a cortisone flare, during the first day or two after the shot. Once the corticosteroid begins its work, the duration of relief can vary widely among individuals and conditions. Generally, a single cortisone shot provides substantial pain relief lasting anywhere from a few weeks to several months, often reported as six weeks to six months.
Key Factors That Influence Duration
The wide range in relief duration is due to biological and anatomical variables specific to the patient and the condition being treated. The severity of the underlying pathology is a major influence, as a joint with mild arthritis changes is likely to experience longer-lasting relief than one with marked degeneration. More purely inflammatory conditions, such as certain types of tenosynovitis, tend to respond better and for a longer period compared to conditions primarily characterized by tissue degeneration.
The anatomical location of the injection also plays a role in how long the effects persist. Injections into larger joints, such as the knee or shoulder, may sometimes provide relief for a longer duration compared to smaller joints or soft tissues. This difference relates to how the medication is absorbed and metabolized within the tissue. Furthermore, the specific type of corticosteroid compound chosen by the physician can influence the potency and half-life of the drug.
Individual patient factors, including metabolism and overall health, contribute to the variability in outcomes. A patient’s activity level or the presence of underlying conditions like diabetes can affect the body’s response to the medication. The goal is to use the pain-free window provided by the injection to engage in physical therapy and other rehabilitative measures, which can help prolong the overall benefit.
Safety Guidelines for Repeat Injections
Because the effects of a cortisone shot are temporary, patients often wonder about repeat injections once the pain returns. Healthcare providers must balance symptom relief with the risks associated with frequent exposure to corticosteroids. The general guideline is to limit the number of injections to no more than three or four per joint or site within a single year.
Spacing the injections out is an important safety measure, requiring a recommended interval of at least 12 weeks between shots in the same location. Overuse of corticosteroids carries the risk of damaging local tissues. Repeated exposure can weaken tendons, making them susceptible to rupture, and may cause deterioration of the joint cartilage.
Frequent injections have been associated with osteonecrosis, the death of nearby bone tissue. Physicians adhere to these frequency limits to prevent cumulative damage. If the relief duration shortens significantly with each subsequent injection, it may indicate that the underlying condition is progressing and that alternative treatments should be considered.

