Hand, Foot, and Mouth Disease (HFMD) is a common viral illness that primarily affects young children but can also be transmitted to adults. This infection is caused by viruses belonging to the Enterovirus genus and is known for causing painful sores in the mouth and a rash on the hands and feet. While generally considered a mild condition that resolves without specific treatment, understanding the timeline of symptoms is helpful for proper monitoring and supportive care.
The Typical Symptom Progression
The typical course of HFMD symptoms generally lasts about seven to ten days from onset to full resolution. The illness begins with a phase that can resemble a common cold, characterized by a mild fever, sore throat, and a general feeling of being unwell. This initial phase usually lasts for one to two days before the more distinct physical signs of the infection appear.
Following the initial fever, the characteristic rash and lesions develop, marking the most uncomfortable phase of the illness. Painful sores often appear in the mouth, on the tongue, gums, and inner cheeks, which can blister and become ulcerated. Concurrently, a non-itchy rash of red spots or small blisters usually emerges on the palms of the hands and the soles of the feet.
These mouth sores typically peak in severity around four to seven days after the first symptoms began. The fever often subsides within two to three days, but the painful mouth ulcers can make swallowing difficult, which sometimes leads to reduced appetite and fluid intake. The blisters on the hands and feet dry up and begin to fade, resolving completely within the seven to ten-day timeframe.
How Long the Virus Remains Contagious
The period of contagiousness involves both the duration of active symptoms and the time the virus continues to shed from the body. An infected person is most contagious during the first week of the illness, particularly when the fever is present and before the rash has fully developed. Transmission occurs through direct contact with fluid from the blisters, respiratory droplets from coughing or sneezing, and contact with contaminated surfaces.
Isolation guidelines for returning to group settings, such as childcare or school, typically require the resolution of acute symptoms. A child can return once the fever has been gone for at least 24 hours without medication and all open blisters have dried up. However, the duration of viral shedding can be significantly longer than the visible illness.
The virus can continue to be shed in the stool for several weeks after the child feels completely better, sometimes lasting two to eight weeks. While the risk of transmission is highest during the acute phase, this prolonged shedding means good hygiene practices like thorough handwashing must continue for an extended period. The virus spreads easily through the fecal-oral route, underscoring the importance of sanitation, especially during diaper changes.
Practical Care and Comfort Measures
Since HFMD is a viral infection, treatment focuses on supportive care and managing discomfort while the illness runs its course. The most significant action is ensuring the patient maintains adequate hydration, which can be challenging due to the painful mouth sores. Offering cold liquids, such as water, milk, or electrolyte solutions, can make swallowing less painful and prevent dehydration.
Pain and fever can be managed with over-the-counter medications like acetaminophen or ibuprofen. Aspirin should never be administered to children or teenagers because of the risk of Reye’s syndrome, a rare but serious condition. Soothing measures involve offering soft, bland foods that require minimal chewing, such as yogurt, puddings, and ice pops, which also provide a cooling effect on the mouth lesions.
Topical oral anesthetics may offer temporary relief for the pain associated with the mouth ulcers, though their use must be monitored carefully, especially in very young children. Resting as much as possible is also beneficial, as the body needs energy to fight the viral infection. This supportive approach helps the patient remain comfortable until the symptoms subside.

