A cortisone shot is a common medical procedure involving the injection of a corticosteroid medication into a specific area, such as a joint or soft tissue, with the primary goal of reducing localized inflammation. This anti-inflammatory effect alleviates pain and improves function for conditions like arthritis or tendonitis. A frequent, temporary side effect is a “cortisone flare,” characterized by increased pain at the injection site shortly after the procedure. This short-term spike in discomfort is a recognized and usually harmless physical reaction.
The Expected Duration of a Cortisone Flare
A cortisone flare is a brief event, typically lasting between 24 and 72 hours (one to three days). The discomfort usually peaks within the first 24 hours following the procedure before gradually subsiding. The timing of the flare is often complicated by the local anesthetic mixed with the steroid, which provides immediate numbness that can wear off within a few hours.
Once the initial numbing effect is gone, the pain from the flare may feel more intense until the corticosteroid medication begins to take effect. If the pain, swelling, or irritation lasts longer than three days, it is important to contact the healthcare provider. Factors such as the specific type of steroid used, the location of the injection, and an individual’s unique physiological response can influence how long the symptoms persist. Patients can generally expect the intended pain relief from the corticosteroid to begin shortly after the flare subsides, typically within a few days to a week.
Understanding the Cause of the Temporary Pain Spike
The primary cause of a cortisone flare is related to the physical properties of the injected medication, which is formulated to include microcrystals of the corticosteroid. These steroid crystals are designed for slow release, allowing the medication to provide long-term pain relief. However, before they dissolve, these tiny particles can act as a temporary irritant at the injection site.
This irritation triggers a localized inflammatory response, which is sometimes referred to as irritant synovitis when it occurs in a joint. The body’s immune cells react to the presence of these crystals, causing the temporary swelling, warmth, and pain that characterize the flare. The flare is a self-limiting condition, meaning it resolves on its own as the crystals begin to dissolve and the medication starts its anti-inflammatory work.
Strategies for Managing Acute Flare Pain
Managing the discomfort of an acute cortisone flare focuses on conservative, at-home treatments to ease symptoms. Rest is a primary recommendation, requiring a patient to protect the injected area for at least the first one to two days after the procedure. Reducing activity and avoiding heavy use of the affected joint allows the localized irritation to calm down.
Applying a cold compress or ice pack to the injection site is effective for reducing the pain and swelling associated with the flare. Ice should be applied for periods of about 15 minutes at a time, using a towel or cloth to avoid applying the ice directly to the skin. Over-the-counter pain relievers can also provide relief, with options including acetaminophen, or nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen. Patients should confirm with their healthcare provider which pain medication is safe to take. Avoid using heat on the injection site during this acute phase, as it can increase inflammation and worsen the discomfort.

