How Long Does It Take for a Cortisone Shot to Work in the Shoulder?

A corticosteroid injection, commonly referred to as a cortisone shot, is a localized medical procedure designed to address inflammation and pain. When administered to the shoulder, the primary goal is to treat conditions like rotator cuff tendinitis, bursitis, or arthritis that involve significant swelling. This treatment is not a cure but a powerful tool to reduce the inflammatory process driving symptoms. By injecting the medication directly into the affected joint space or soft tissue, physicians provide concentrated relief, facilitating participation in physical therapy and rehabilitation.

How Cortisone Works to Reduce Inflammation

A cortisone shot is a mixture of two distinct medications. The mixture typically contains a synthetic corticosteroid, the long-term anti-inflammatory agent, and a fast-acting local anesthetic, such as lidocaine. The immediate effect felt by the patient is due to the anesthetic, which quickly numbs the injection site and surrounding painful structures.

The corticosteroid component is a potent anti-inflammatory drug that mimics cortisol, a hormone naturally produced by the adrenal glands. Once injected, the steroid suppresses the immune response directly at the site of inflammation. This mechanism involves blocking the production of chemicals that cause swelling, redness, and pain.

By reducing this chemical cascade, the steroid decreases inflammation within the shoulder joint or bursa. Common corticosteroids, such as methylprednisolone or triamcinolone, are formulated as micro-crystals that are slowly absorbed by the body. This slow-release nature provides the prolonged therapeutic effect, allowing the irritated tissue to settle down.

The Expected Timeline for Pain Relief

The relief timeline for a shoulder cortisone shot unfolds in two distinct phases. The first phase is almost immediate, occurring within minutes to a few hours after the injection, and is entirely attributable to the local anesthetic. This immediate numbing effect offers patients a temporary window of pain reduction.

The anesthetic is short-lived, typically wearing off after a few hours, and the original pain may temporarily return. This period, before the steroid begins to work, is a normal part of the process. The second, more therapeutic phase begins when the corticosteroid crystals start to exert their anti-inflammatory action.

The therapeutic effect generally begins to manifest within three to seven days following the procedure. For individuals with more severe or chronic inflammation, it may take up to ten days before they notice substantial improvement in pain and mobility. The true benefit is the gradual, sustained reduction of swelling that allows the shoulder to function with less restriction.

Immediate Care and Potential Flare-Ups

Following a cortisone injection, patients are advised to take specific care steps during the first 24 to 48 hours. It is recommended to rest the shoulder and avoid strenuous activity, heavy lifting, or intense exercise during this initial period. Patients should also avoid submerging the injection site; showers are preferred over baths, hot tubs, or swimming pools for a few days.

A temporary phenomenon known as a “cortisone flare” may occur, causing a short-term increase in pain and inflammation at the injection site. This flare-up is thought to be a reaction to the slow-releasing steroid crystals and usually begins within the first day or two after the procedure. This discomfort is short-lived, resolving on its own within 48 hours.

Managing a flare-up involves applying ice packs to the shoulder for brief periods, such as 15 minutes at a time, to soothe the localized irritation. Non-prescription pain relievers may also be used to manage the temporary discomfort. It is important to avoid applying heat to the area, as this can increase local inflammation.

Variables Affecting Long-Term Results

The effectiveness and duration of relief from a shoulder cortisone shot are influenced by several patient and procedure-specific factors. Precision of needle placement is a significant variable; utilizing imaging technology like ultrasound guidance helps ensure the medication is delivered directly to the inflamed bursa or joint space, improving the likelihood of a positive outcome. The severity of the underlying issue also plays a role, as an injection for mild bursitis may last longer than one given for advanced osteoarthritis.

Patient-specific factors, including individual metabolism and body chemistry, determine how quickly the steroid is absorbed and cleared from the joint. The specific corticosteroid preparation used can affect the duration of relief, as different types have varying half-lives. For patients who respond well, relief commonly ranges from several weeks to many months, often providing a therapeutic window of three to six months.

If a patient experiences no noticeable improvement after seven to fourteen days, the underlying diagnosis may need reassessment or an alternative treatment path is necessary. Because repeated corticosteroid injections may have detrimental effects on joint cartilage and tendons, physicians typically limit the number of shots, recommending no more than three injections into the same area per year.