Molluscum Contagiosum (MC) is a common viral skin infection caused by a poxvirus, resulting in small, raised, pearl-like bumps on the skin. These dome-shaped lesions are painless and benign, but their appearance and contagiousness often cause concern. The duration of a molluscum infection is highly variable, depending on whether the condition is left to clear naturally or is treated with medical intervention.
The Untreated Timeline: Natural Resolution
Molluscum contagiosum is a self-limited infection, meaning it will eventually resolve on its own without any medical treatment. For individuals with a healthy immune system, the average time for the entire outbreak to clear is around 13 months, though the infection can occasionally persist for as long as two to four years. While a single molluscum bump typically resolves within two to twelve months, the total duration is extended by the cycle of auto-inoculation. New lesions continuously appear as older ones heal because the virus spreads easily through scratching or rubbing. Resolution is often signaled by inflammation, where the lesion becomes red, swollen, and crusty, indicating the body is mounting an effective immune response.
Factors That Influence Healing Duration
Several non-treatment related factors inherent to the patient and the infection itself can significantly affect the healing timeline. The status of the immune system is a primary determinant, as the infection tends to be more persistent and widespread in immunocompromised individuals. Underlying skin conditions, particularly atopic dermatitis or eczema, can also prolong the infection by disrupting the skin barrier and leading to a more extensive outbreak. Furthermore, the location and sheer number of lesions play a role, as a large number of clustered lesions may take longer to clear completely than a small, isolated group.
Treatment Options and Their Impact on Resolution Time
Seeking treatment is a proactive way to shorten the overall duration of the molluscum outbreak compared to waiting for natural resolution. Medical intervention aims to physically or chemically destroy existing lesions, which stops them from shedding the virus and prevents the formation of new bumps. By breaking the cycle of auto-inoculation, treatment significantly accelerates the time to clear skin.
In-Office Procedures
In-office, destructive methods aim to remove lesions quickly, often resulting in resolution within one to two weeks after the treated area heals. Common procedures include cryotherapy (freezing the bumps with liquid nitrogen) and curettage (physical scraping away of the lesion). Cantharidin, a blistering agent applied directly to the lesions, is another effective option that causes them to lift off the skin.
Topical Medications
Topical medications are frequently used and work by inducing a localized inflammatory reaction to prompt an immune response against the virus. These at-home treatments include compounds like topical retinoids, salicylic acid with iodine, or immune modulators, applied directly over several weeks or months. While topical treatments may take several weeks to months for full resolution, they are often preferred for children due to their less invasive nature compared to physical removal.
The most effective approach often involves a combination of these methods, requiring follow-up appointments necessary to treat new lesions as they appear. Treatment rapidly reduces the viral load on the skin, which is the most direct way to contain the infection and achieve clear skin more quickly.
Preventing the Spread of Molluscum Contagiosum
Diligent management practices are important to prevent the virus from spreading, regardless of whether treatment is pursued. The primary concern is auto-inoculation, which is the spread of the virus to uninfected areas of one’s own body, often caused by scratching or shaving over the lesions. Avoiding any trauma to the bumps is the most effective way to prevent the outbreak from becoming more widespread and prolonging the duration.
To contain the infection and prevent transmission, maintaining these habits until all lesions have completely disappeared is necessary:
- Keep lesions covered with clothing or a watertight bandage, especially during activities involving close contact or water, such as swimming or contact sports.
- Practice good hand hygiene, including frequent washing with soap and warm water, to prevent accidental transfer of the virus.
- Avoid sharing personal items that come into direct contact with the skin, such as towels, washcloths, clothing, or athletic equipment.
- Using separate items helps contain the infection and prevent its spread to other members of the household, because the virus can survive on these surfaces.

