Serrapeptase is a systemic enzyme supplement often used for its anti-inflammatory and fibrinolytic properties. While it is not a fast-acting solution, understanding the enzyme’s origin, mechanism of action, and the factors influencing its timeline can set realistic expectations for those considering its use for scar reduction.
Serrapeptase: Origin and General Function
Serrapeptase, or serratiopeptidase, is a proteolytic enzyme that breaks down proteins. This unique enzyme was originally isolated from the Serratia marcescens bacteria found in the digestive system of the silkworm. The silkworm uses this enzyme to dissolve its hardened cocoon, allowing the moth to emerge.
Researchers in Japan first isolated the enzyme in the late 1960s, noting its anti-inflammatory effects. Serrapeptase has been routinely used in medical practices across Europe and Asia for decades to manage swelling, pain, and various inflammatory conditions. Its function revolves around digesting non-living or damaged protein matter, which forms the basis for its therapeutic applications.
The Biological Mechanism of Scar Reduction
Serrapeptase helps reduce scar tissue appearance due to its ability to break down proteins. Scars are primarily composed of excess collagen and fibrin, a tough, fibrous protein the body uses to create a structural mesh during healing. Serrapeptase exhibits fibrinolytic activity, targeting and degrading excess fibrin and damaged tissue without harming healthy cells.
By breaking down this fibrous material, the enzyme helps reduce the density and fibrous nature of the scar. This action facilitates the body’s natural process of tissue remodeling, helping to replace disorganized scar tissue with smoother tissue. Serrapeptase also reduces inflammation and swelling, which contributes to the scar’s appearance and density. Reducing localized swelling improves microcirculation, allowing nutrients and oxygen to better reach the affected area and support healing.
Realistic Timelines and Influencing Factors
The timeline for Serrapeptase to affect scar tissue depends on individual and scar-specific factors. The enzyme works gradually, targeting dense protein buildup over time. Most users begin to notice subtle changes in the texture, color, or mobility of the affected area after a period of consistent use, typically ranging from a few weeks to several months.
The age and type of the scar are the most significant factors influencing the timeline. Newer scars, which are still actively remodeling, may show subtle improvements within three to six weeks. Older, established, or denser scar tissue, such as hypertrophic or keloid scars, requires a much longer duration, often needing consistent use for two to six months or more before meaningful changes are observed.
The individual’s metabolic rate, the severity of the scar, and the dosage consistency also play a significant role. For the enzyme to be effective, it must be absorbed into the bloodstream in sufficient concentration to reach the target tissue. Since the enzyme is relatively large, it takes time for it to penetrate deep tissues and break down the fibrous material.
Safety Considerations and Proper Usage
Proper administration is necessary for Serrapeptase to be effective due to its sensitivity to stomach acid. The supplement must be enteric-coated; this protective layer prevents the capsule from dissolving in the stomach’s acidic environment. This ensures the enzyme safely reaches the small intestine for absorption into the bloodstream.
To maximize systemic absorption, it is recommended to take Serrapeptase on an empty stomach, typically 30 minutes before eating or two hours after a meal. Standard dosage recommendations range from 10 mg to 60 mg per day. Enzyme activity is often measured in SPU (Serratiopeptidase Units), where 10 mg equals approximately 20,000 SPU.
The primary safety concern relates to Serrapeptase’s potential effect on blood clotting. Because the enzyme has mild blood-thinning properties, it should not be taken with anticoagulant or antiplatelet medications like Warfarin or aspirin. Due to the increased risk of bruising and bleeding, users should stop taking Serrapeptase at least two weeks before any scheduled surgery.