A single 150 mg tablet of generic fluconazole, the most commonly prescribed dose for a yeast infection, starts around $6.29 at retail pharmacies without insurance. With a free discount coupon, that price can drop to under $4. The exact amount depends on the strength, quantity, and pharmacy you use.
Price by Strength and Quantity
Fluconazole comes in several tablet strengths, and the total cost shifts depending on how many pills your prescription requires. Here’s what the common oral tablets cost at retail without insurance:
- 150 mg (1 tablet): $6.29. This is the standard single-dose treatment for vaginal yeast infections and the most frequently searched price. Two tablets cost about $8.34.
- 50 mg (30 tablets): Starting around $19.89, or about $0.66 per tablet. Larger quantities bring the per-pill cost down to roughly $0.56.
- 100 mg (10 tablets): Starting around $9.69, or about $0.97 per tablet. A 30-count drops to roughly $0.69 each.
- 200 mg (20 tablets): Starting around $21.38, or about $1.07 per tablet. A 30-count runs close to $30.
Higher quantities generally lower the per-unit cost. If your doctor prescribes a longer course for a systemic fungal infection or maintenance therapy for recurring yeast infections, buying in larger quantities can save money over time.
How Prices Vary by Pharmacy
Cash prices for the same medication can differ significantly from one pharmacy to the next, even within the same zip code. For 30 tablets of fluconazole 200 mg, for example, one comparison found Stop & Shop Pharmacy charging about $22, CVS around $30, and Walgreens closer to $38. That’s a $16 spread for the identical generic product. Costco, independent pharmacies, and grocery store pharmacies often price generics lower than the big chains, so it’s worth calling around or checking prices online before filling your prescription.
Discount Coupons and Savings Programs
Free prescription discount programs can cut the cost dramatically. GoodRx lists fluconazole 150 mg (2 tablets) for as low as $3.92 at Walgreens with a coupon, which represents an 85% discount off the average retail price of about $27. Similar savings are available through other discount platforms, where prices around $4.86 for a single 150 mg tablet have been reported at participating pharmacies.
These coupons are free to use and don’t require insurance. You simply show the coupon (on your phone or printed) to the pharmacist at checkout. The prices change frequently, so checking right before you fill the prescription gives you the most accurate number.
Brand-Name Diflucan Costs More
Fluconazole is the generic version of Diflucan, which lost its patent protection years ago. Nearly every pharmacy dispenses the generic by default, and it contains the same active ingredient at the same dose. Brand-name Diflucan, if you specifically request it, costs substantially more. Most people have no reason to ask for the brand version, and pharmacists will automatically substitute the generic unless your prescription says otherwise.
The Cost of Getting the Prescription
Fluconazole requires a prescription, so the tablet price isn’t your only expense. Without insurance, a telehealth visit to get a yeast infection diagnosed and treated runs about $33 to $79 depending on the platform. Walgreens Virtual Healthcare, for instance, charges $39 for a yeast infection visit conducted over chat or video. The clinician can send the fluconazole prescription directly to the pharmacy of your choice.
That puts the total out-of-pocket cost for a straightforward yeast infection, including the visit and the medication, somewhere between $40 and $85 without insurance. Using a discount coupon on the medication side brings it closer to the lower end of that range.
Longer Treatment Courses
A one-time yeast infection typically requires just a single 150 mg tablet. But some conditions call for weeks or months of daily fluconazole at higher doses. Systemic fungal infections, for example, may require 200 mg daily for extended periods. Recurring yeast infections are sometimes managed with a weekly 150 mg dose for six months.
For a six-month maintenance plan at one tablet per week, you’d need roughly 24 to 26 tablets. At the 12-count price of about $2.05 per tablet, that comes to around $50 to $55 total for the medication. Buying larger quantities at once, combined with a discount coupon, can push this lower. If your treatment involves daily 200 mg tablets for 30 days, expect to pay roughly $22 to $30 at the most competitive pharmacies, or less with coupons.