Intramuscular (IM) injections deliver medications, vaccines, and supplements directly into muscle tissue for rapid uptake into the bloodstream. The ventrogluteal (VG) injection targets the gluteus medius and gluteus minimus muscles, located on the side of the hip. Healthcare professionals widely recognize this site as a preferred location for delivering larger volumes of medication, typically up to 3 milliliters, safely and effectively. This guide outlines the proper procedures for safely performing a ventrogluteal injection, focusing on accurate site identification and precise technique.
Advantages of the Ventrogluteal Site
The ventrogluteal area is the safest injection site due to its anatomical separation from major neurovascular structures. The gluteus medius and minimus muscles are thick and well-developed, providing substantial muscle mass for medication absorption. This muscle bulk is situated away from the sciatic nerve and large blood vessels, significantly lowering the risk of accidental nerve damage.
Compared to the traditionally used dorsogluteal site (the upper outer quadrant of the buttock), the VG site offers a distinct safety advantage. The dorsogluteal region is closer to the sciatic nerve, risking temporary or permanent paralysis if injured. Additionally, the subcutaneous tissue layer over the ventrogluteal muscle is often thinner, increasing the likelihood that the needle reaches the intended muscle layer for optimal absorption and potentially resulting in less post-injection pain.
Preparation and Positioning
Strict hand hygiene must be performed before approaching the patient. Gather all necessary supplies on a clean workspace, including the medication-filled syringe, an appropriate needle, alcohol swabs, sterile gauze, and a puncture-proof sharps container. Needle selection should be based on the patient’s size and medication viscosity, with typical adult lengths ranging from one to one and a half inches and gauges between 20 and 25.
Positioning the patient correctly helps relax the gluteal muscles and facilitates accurate landmarking. The patient should be placed in a side-lying position on the side opposite the intended injection site. Asking the patient to slightly flex the knee and hip of the upper leg helps relax the gluteal muscles, making landmarks easier to locate. The injection site must be fully exposed while ensuring the patient’s privacy is maintained.
Identifying the Injection Landmarks
Accurate anatomical landmarking is necessary to ensure the injection is delivered into the correct muscle. The ventrogluteal site is located using a specific three-point technique, often called the V-method. The practitioner places the heel of their hand over the greater trochanter of the femur (the bony prominence on the side of the hip).
The hand used for landmarking should be opposite the hip being injected (e.g., use the right hand for the patient’s left hip). The practitioner points their thumb toward the patient’s groin and extends the index finger toward the anterior superior iliac spine (ASIS). The middle finger is then spread away from the index finger, following the line of the iliac crest (the curved upper border of the hip bone). This configuration forms a distinct “V” shape. The correct injection site is within the center of this V, which corresponds to the thickest part of the gluteus medius and minimus muscles. Once the site is located, it should be held in place for the next steps.
Administering the Injection
Site Preparation and Stabilization
After identifying the site, clean the skin thoroughly using an alcohol swab, wiping outward from the center. Allow the area to air dry completely before insertion to prevent stinging. The preferred method for stabilizing the skin is the Z-track technique, where the skin is pulled laterally or downward by the non-dominant hand. This method helps seal the medication deep within the muscle tissue after withdrawal, preventing leakage into the subcutaneous layer.
Needle Insertion and Aspiration
Insert the needle quickly, with a smooth, dart-like motion, at a 90-degree angle to the skin surface to ensure muscle penetration. Once fully inserted, the practitioner may briefly aspirate by gently pulling back on the syringe plunger for five to ten seconds. While aspiration is a traditional step to check for entry into a blood vessel, current evidence suggests it may not be necessary for all medications or at this specific site.
Medication Delivery
If blood appears upon aspiration, withdraw the needle immediately, and repeat the procedure using new supplies and a different injection site. If no blood is aspirated, inject the medication slowly and steadily, typically at a rate of about 10 seconds per milliliter. This rate improves patient comfort and allows the muscle to accommodate the fluid volume. After delivery, quickly withdraw the needle, and release the skin, allowing the tissue layers to slide back and “lock” the medication in place.
Post-Procedure Safety and Disposal
Immediately after withdrawal, apply sterile gauze to the injection site using gentle pressure. Do not massage the area, as this can force medication back into the subcutaneous tissue or cause irritation. Monitor the patient briefly for adverse reactions, such as excessive bleeding, severe pain, or signs of an allergic response.
Proper documentation must be completed, recording the medication, dose, time, the specific ventrogluteal site used, and the patient’s response. The final safety step is the immediate disposal of the used syringe and needle. The sharp device must be discarded as a single unit, without recapping or bending the needle, directly into a designated, puncture-proof sharps container located within arm’s reach. This prevents accidental needle-stick injuries.

