The seasonal influenza shot is a medical procedure designed to prevent infection from circulating influenza viruses or lessen the severity of the illness if infection occurs. This vaccine stimulates the body’s immune system to produce antibodies that recognize the specific strains included in the annual formulation. The administration of the vaccine is a precise process performed exclusively by trained healthcare professionals (HCPs) to ensure both patient safety and vaccine effectiveness.
Essential Pre-Vaccination Steps
The process of vaccination begins with a thorough safety screening to determine a patient’s readiness for the shot. Healthcare providers must confirm the patient does not have a current moderate or severe illness, especially one accompanied by a high fever, which would typically warrant rescheduling the appointment. Screening also involves checking for any history of severe allergic reactions, such as anaphylaxis, to a previous flu vaccine component or to the vaccine itself.
Contraindications, which are specific conditions that make receiving the vaccine unsafe, are carefully reviewed. Severe allergic reactions are extremely rare. While some flu vaccines are manufactured using egg-based technology, the vaccine is considered safe for most people with an egg allergy. However, a severe reaction history may require the shot to be given in a specialized medical setting. After confirming the patient is suitable, informed consent is obtained, ensuring the patient understands the procedure and its potential effects.
The HCP selects and prepares the injection site, typically the deltoid muscle in the upper arm for adults and older children. For infants and toddlers, the preferred site is the vastus lateralis muscle in the anterolateral thigh, which provides a larger muscle mass. The chosen area is cleansed with an antiseptic wipe, such as an alcohol swab. The site must be allowed to air-dry completely before injection to prevent bacteria from entering the puncture site and minimize stinging.
The Standard Intramuscular Injection Technique
The flu shot is administered as an intramuscular (IM) injection, delivered deep into the muscle tissue to ensure proper absorption and an optimal immune response. The correct needle selection is based on the patient’s age, weight, and the amount of adipose tissue over the muscle. For most adults, a 22- to 25-gauge needle with a length between 1 and 1.5 inches is used to reach the deltoid muscle.
The healthcare provider holds the syringe like a dart and stabilizes the muscle tissue at the injection site. The needle is inserted with a quick, single thrust at a 90-degree angle to the skin. This angle is standard for IM injections and ensures the vaccine bypasses the subcutaneous fat layer. Injecting the vaccine into the muscle tissue is essential, as delivery into fatty tissue may reduce effectiveness and increase the risk of local reactions.
Once the needle is properly positioned, the HCP depresses the plunger slowly and steadily to inject the full dose of vaccine. Injecting the vaccine slowly helps minimize patient discomfort during the procedure. After delivery, the needle is withdrawn quickly, and a dry cotton ball or gauze is immediately applied to the site to apply pressure. The used syringe and needle are then safely disposed of into a sharps container, preventing accidental needle-stick injuries.
Immediate Post-Injection Monitoring and Care
Following the injection, patients are advised to remain in the clinic or pharmacy for a standard 15-minute observation period. This waiting time is a safety precaution to monitor for any immediate, severe adverse reactions, such as anaphylaxis. Signs of a serious reaction can include difficulty breathing, wheezing, swelling of the face or throat, hives, or a rapid heartbeat.
The HCP simultaneously completes the necessary administrative documentation, recording the specific vaccine product, lot number, site, and date of administration in the patient’s medical record. Patients are informed that mild and temporary side effects are common, such as soreness, redness, or slight swelling at the injection site. Moving the arm frequently after the shot is recommended to help reduce soreness and stiffness.
Other mild systemic effects, such as a headache, low-grade fever, or muscle aches, may occur and usually resolve within one to two days. Patients are instructed to seek immediate medical attention if they experience signs of a severe allergic reaction after leaving the facility. Applying a cold compress can help manage local discomfort. Over-the-counter pain relievers may be used if needed, though some experts suggest using these sparingly to avoid potentially blunting the immune response.

