The eastern copperhead (Agkistrodon contortrix) is a widespread venomous snake found throughout the eastern and central United States. This species is a member of the pit viper family, which is characterized by the presence of heat-sensing pits between the eyes and nostrils used to locate prey. Copperheads are responsible for more venomous snakebites in the US than any other species, primarily due to their abundance and tendency to “freeze” rather than flee when approached. They are identifiable by their distinctive hourglass-shaped crossbands, which are dark brown or reddish-brown, overlaid on a lighter background.
The Specifics of Copperhead Venom
The venom produced by the copperhead is classified as hemotoxic, meaning its primary effect is the breakdown of blood cells and local tissue. This venom contains enzymes that cause tissue damage, leading to symptoms like pain and swelling. Hemotoxic properties are common among pit vipers, a group that includes rattlesnakes and cottonmouths.
Compared to the venom of other North American pit vipers, copperhead venom has a lower potency. Studies show it exhibits the lowest hemorrhagic and myotoxic activities among Agkistrodon species. The venom’s function is primarily to immobilize and begin digesting small prey, such as rodents and insects.
Severity and Common Outcomes of Bites
Copperhead bites are rarely fatal to healthy humans, making them the least dangerous venomous snake in the United States. Most envenomations are mild to moderate, with only about 2% meeting the criteria for severe outcomes. This low danger level is partly because the snake often delivers a “warning bite.”
Approximately 25% of strikes are “dry bites,” where no venom is injected. When envenomation occurs, the most common symptoms are intense, localized pain and progressive swelling at the bite site. Local tissue effects, including bruising and redness, typically peak within 24 to 48 hours.
Although major complications are uncommon, a bite causes significant discomfort and temporary disability. Pain often lasts about seven days, and swelling persists for around ten days. Bites to the fingers and toes tend to result in more concentrated local damage. Systemic effects, such as gastrointestinal symptoms or minor coagulation abnormalities, are rare.
Immediate Response and Medical Treatment
Following a confirmed or suspected copperhead bite, remain calm and seek professional medical attention immediately. Keep the affected limb below the level of the heart to slow venom spread, and remove constricting items like rings or watches before swelling begins. Do not use a tourniquet, cut the wound, or try to suck out the venom, as these actions are ineffective and cause further harm.
In the hospital, medical professionals provide supportive care, including pain management and monitoring of local symptoms. The antivenom used for North American pit viper envenomations is Crotalidae Polyvalent Immune Fab (CroFab). Antivenom administration is reserved for severe cases, such as those with rapidly progressing symptoms, significant local tissue damage, or systemic effects.
The decision to use antivenom is based on the severity of the patient’s symptoms. When administered, the antivenom works by binding to and neutralizing venom components, halting the progression of swelling and potential coagulation issues. Patients who do not require antivenom are typically observed for at least eight hours to ensure local effects do not worsen.
Habitat and Preventing Encounters
Copperheads thrive in diverse environments, commonly inhabiting wooded areas, rocky hillsides, and mixed woodlands. They are also found in suburban areas, often concealing themselves within leaf litter, brush piles, and under logs or rocks. Their excellent camouflage leads to accidental encounters when people step near them.
Prevention focuses on reducing accidental contact in known copperhead areas. When walking outdoors, wear sturdy, closed-toe shoes or boots and stick to established trails. Avoid placing hands or feet where visibility is limited, such as reaching under logs or stepping over thick brush.
Reducing attractive habitats around the home is an effective preventative measure. This includes regularly clearing yard debris, trimming overgrown vegetation, and keeping firewood stacked neatly away from the house. Use a flashlight when walking outside at night, as copperheads are often more active during warmer evening hours.

