A mouse bite introduces risks due to the bacteria carried in the rodent’s mouth and saliva. Most bites occur when the animal feels cornered or threatened, resulting in a small puncture wound. The primary danger lies not in the injury itself, but in the potential for infection and disease transmission. Immediate, proper action is necessary to minimize the risk of serious health complications.
Immediate First Aid Steps After a Bite
The first step after a mouse bite is to thoroughly cleanse the wound to reduce the introduction of pathogens. Immediately wash the affected area with mild soap and warm running water for a minimum of five minutes. This extended washing helps flush out contaminants transferred from the mouse’s teeth or saliva.
After washing, carefully dry the area with a clean towel and apply an antiseptic solution, such as hydrogen peroxide, to the puncture site. If the wound is still bleeding, apply gentle, firm pressure with a clean cloth until the bleeding stops. Once the area is clean and dry, apply an over-the-counter antibiotic ointment and cover the bite with a sterile bandage.
Understanding the Specific Disease Risks
The most significant health risk transmitted directly through a mouse bite is Rat-Bite Fever (RBF), caused by bacteria living naturally in a rodent’s mouth and throat. In the United States, the most common causative agent is the bacterium Streptobacillus moniliformis. This organism is part of the normal flora for many rodents, meaning the animal does not have to appear sick to be a carrier.
A bite introduces bacteria, potentially leading to a severe, systemic infection requiring immediate antibiotic treatment. Beyond RBF, any animal bite that breaks the skin carries a risk of secondary bacterial infections, such as cellulitis. Diligent wound care is necessary to prevent these localized infections.
While people often worry about rabies after an animal bite, the risk of transmission from mice is extremely low. Small rodents rarely carry the rabies virus in the United States and Canada. The focus following a mouse bite should remain on the higher probability of bacterial infections like Rat-Bite Fever.
Identifying Signs That Require Medical Attention
Any mouse bite should prompt a call to a healthcare provider, but specific symptoms indicate the bite has progressed into a serious, systemic illness like RBF. Symptoms of RBF typically begin three to ten days after the initial exposure, although they can be delayed up to 21 days, often appearing after the original bite wound has healed. Early signs often resemble the flu, including an abrupt onset of fever, chills, severe headache, and vomiting.
Within a few days of the fever starting, approximately half of infected individuals experience joint pain or swelling, and a rash may appear on the hands and feet. The rash is often described as small, flat, reddened areas with bumps. Localized signs of infection at the bite site include increasing swelling, spreading redness, worsening pain, or pus/discharge.
Confirming your tetanus vaccination status is important after any puncture wound. If the wound is deep or dirty and you have not had a booster shot in the last five years, a healthcare provider may recommend one. Prompt medical care is necessary because untreated RBF can lead to severe complications, such as infections of the heart, lungs, or brain, and has a mortality rate of over 10%.
How Risk Differs Between Wild, Pet, and Lab Mice
The risk of disease transmission from a mouse bite varies significantly based on the animal’s environment and source. Wild mice carry the highest risk of transmitting pathogens like Streptobacillus moniliformis (the RBF agent), as they live in uncontrolled environments. They are regularly exposed to various bacteria and viruses, and also carry a greater risk of transmitting diseases like Lymphocytic Choriomeningitis (LCMV). Transmission of these diseases occurs through their saliva, urine, and feces.
Pet mice, while generally carrying a lower risk than their wild counterparts, can still transmit RBF and other infections. Even well-cared-for domestic mice can be carriers if they come into contact with wild rodents or contaminated food and water. The Centers for Disease Control and Prevention advises caution when keeping pet rodents, especially for people with weakened immune systems.
Laboratory mice used in research settings carry the lowest risk of disease transmission to humans. These animals are maintained in highly controlled environments and are routinely screened for various disease agents, including those that cause RBF. The primary health concern for people working with lab rodents is the development of allergies to animal dander and urine, rather than infection.

