Yes, generic Vyvanse (lisdexamfetamine) is available in the United States. The FDA approved several generic versions in August 2023, after Vyvanse’s patents expired earlier that year. Multiple manufacturers now produce it in both capsule and chewable tablet forms, and the generic version typically costs a fraction of the brand-name price.
What Generic Options Are Available
Generic lisdexamfetamine comes in two forms: capsules and chewable tablets. The capsules are available in 10, 20, 30, 40, 50, 60, and 70 mg strengths, matching the full brand-name lineup. Chewable tablets cover 10 through 60 mg but do not come in a 70 mg strength, so if you take the highest dose, capsules are your only option.
Several manufacturers produce the generic, including Hikma, Mallinckrodt, Mylan (Viatris), Solco, and Teva. All contain the same active ingredient as brand-name Vyvanse. The inactive ingredients (fillers, dyes, capsule materials) can differ slightly between manufacturers, which rarely matters unless you have a specific allergy to a dye or filler. If that’s a concern, your pharmacist can pull up the inactive ingredient list for whichever manufacturer they stock.
How Much the Generic Costs
The price difference between generic and brand-name Vyvanse is substantial. A 30-day supply of generic lisdexamfetamine capsules starts around $55 to $70 at major pharmacies when using a discount card or coupon. Brand-name Vyvanse, by comparison, runs roughly $380 to $410 for the same quantity. That’s a savings of around 80% or more depending on the dose and pharmacy.
Your actual out-of-pocket cost depends on your insurance. Most plans now place generic lisdexamfetamine on a preferred tier (typically Tier 2), which means a lower copay than the brand. Some plans, including the VA formulary, require prior authorization before covering it, but that’s a paperwork step your prescriber handles. If your pharmacy tries to fill the brand name by default, ask specifically for the generic.
Supply Shortages in 2025
Here’s the catch: generic lisdexamfetamine has been affected by ongoing supply problems. As of 2025, every major generic manufacturer is reporting some level of shortage. Hikma and Solco have all their lisdexamfetamine capsule strengths on allocation, meaning pharmacies can only order limited quantities. Mallinckrodt has its 10 mg capsules on back order with an estimated release date of May 2026, and its other strengths are in limited supply. Mylan has its 20 mg capsules on back order with no estimated release date. Teva’s 70 mg capsules are in limited supply.
The primary reason cited by most manufacturers is an issue with the active ingredient supply itself, not a manufacturing problem on their end. In practical terms, this means your pharmacy may not have your specific dose in stock on any given day. A few strategies that help: call your pharmacy a few days before your refill is due to confirm availability, ask your pharmacist to check other nearby locations, and try different pharmacy chains since each may source from different manufacturers.
Generic vs. Brand: What’s Actually Different
The active drug in generic lisdexamfetamine works identically to Vyvanse. The FDA requires generics to deliver the same amount of medication into your bloodstream within a tight range (80% to 125% of the brand’s performance in bioequivalence testing). In practice, most generics fall much closer to 100% than those outer bounds suggest.
What can differ are the inactive ingredients: the fillers that hold the capsule together, the dyes that color it, and the binders in chewable tablets that affect taste and texture. Some people notice the chewable tablets taste different across manufacturers, or that a capsule from one company looks different from another. These cosmetic differences don’t change how the medication works. If you switch manufacturers and genuinely feel the medication isn’t working as well, talk to your prescriber, but this is uncommon with lisdexamfetamine because the drug itself is a prodrug that your body converts in a very consistent way regardless of the delivery vehicle.
How to Get the Generic Filled
If your prescriber writes “Vyvanse” on your prescription, most pharmacies will automatically substitute the generic unless the prescription specifically says “dispense as written” or “DAW.” In most states, pharmacists are allowed (and often required by insurance) to make this substitution. If you’re currently paying brand-name prices and haven’t been offered the generic, ask your pharmacist directly.
For people without insurance or with high-deductible plans, discount programs through GoodRx, SingleCare, or RxSaver can bring the generic price down to that $55 to $70 range for a 30-day supply. These work at most major chain pharmacies and don’t require insurance. Just present the coupon at pickup. Given the current shortage situation, though, price may be less of a barrier than simply finding a pharmacy that has it in stock.