Yes, generic Vyvanse is available. The FDA approved generic versions of lisdexamfetamine (the active ingredient in Vyvanse) on August 25, 2023, with more than a dozen manufacturers authorized to produce it. Both capsule and chewable tablet forms are now on the market.
What Was Approved
The FDA approved generic lisdexamfetamine in two forms: capsules in seven strengths (10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, and 70 mg) and chewable tablets in six strengths (10 mg through 60 mg). These match the same dosages available for brand-name Vyvanse.
Thirteen companies received approval to manufacture the generic capsules, including major generic drugmakers like Mylan, Teva, Sun Pharmaceutical, and Amneal. Three companies were approved for the chewable tablets. Having this many manufacturers is significant because it creates competition that should push prices down over time and help prevent supply gaps.
How Generic Compares to Brand-Name
The FDA has determined generic lisdexamfetamine to be bioequivalent and therapeutically equivalent to brand-name Vyvanse. That means the generic delivers the same amount of the active drug into your bloodstream at the same rate. You should expect the same effects, the same duration of action, and the same side effect profile.
The inactive ingredients (fillers, dyes, coatings) can differ between manufacturers and from the brand name. In rare cases, people notice minor differences in how quickly a pill dissolves or how they feel on a particular manufacturer’s version. If that happens, you can ask your pharmacist to fill your prescription from a different generic manufacturer.
What It Costs
Without insurance, brand-name Vyvanse runs about $558 for a 30-day supply of 30 mg capsules. Generic lisdexamfetamine averages around $433 for the same quantity and strength. That’s roughly a 22% savings, which is smaller than the discount you’d typically see with generics for older medications. The gap is likely to widen as more manufacturers ramp up production and compete on price.
With insurance, your out-of-pocket cost depends on your plan’s formulary. Many insurers have started placing generic lisdexamfetamine on a preferred tier, which means lower copays compared to the brand. Some plans now require you to use the generic unless your prescriber specifically requests the brand version and provides a medical reason. If your plan still lists Vyvanse at a high copay tier or requires prior authorization, asking your doctor to write the prescription for generic lisdexamfetamine may simplify the process.
Shortage Issues
Stimulant medications, including lisdexamfetamine, have been affected by ongoing drug shortages in the United States. The American Society of Health-System Pharmacists first flagged lisdexamfetamine capsules as being in shortage in June 2023, shortly before the generics launched, and the shortage listing was still being updated as of late 2025. This means certain strengths or certain manufacturers’ products may be temporarily unavailable at your pharmacy.
If your pharmacy is out of stock, a few practical steps can help. Call other pharmacies in your area, including independent pharmacies that sometimes have stock when chains don’t. Ask your pharmacist whether a different manufacturer’s generic is available. Your prescriber can also adjust to a nearby strength if one specific dosage is harder to find. Because lisdexamfetamine is a Schedule II controlled substance, prescriptions can’t simply be transferred between pharmacies in every state, so check your state’s rules or have your doctor send a new prescription to the pharmacy that has it in stock.
How to Get It
Your doctor can prescribe generic lisdexamfetamine the same way they would prescribe Vyvanse. In most states, pharmacists will automatically substitute the generic unless the prescriber writes “dispense as written” or “brand name medically necessary.” If you’re currently taking brand-name Vyvanse and want to switch, you typically don’t need a new prescription. Just let your pharmacist know you’d like the generic at your next refill.
Keep in mind that lisdexamfetamine is a Schedule II controlled substance, so the same prescribing rules apply to the generic as to the brand. You’ll still need a new prescription for each fill (no automatic refills in most states), and there are limits on how early you can pick up your next supply, typically no more than a few days before you run out.