Pneumonia, an infection of the lungs often caused by Streptococcus pneumoniae bacteria, remains a serious public health concern, especially for young children and older adults. The pneumococcal vaccine is a powerful tool to prevent this disease, which can lead to severe infections like meningitis and bacteremia. Understanding what recipients can realistically expect after vaccination is valuable. This information should clarify the difference between normal, temporary side effects and the extremely rare severe reactions.
Understanding the Different Pneumonia Vaccines
The pneumococcal vaccines protect against the bacteria that cause the most common and severe infections. The specific shot a person receives depends on their age and underlying health conditions. There are two main types of pneumococcal vaccines used: the Pneumococcal Conjugate Vaccines (PCV) and the Pneumococcal Polysaccharide Vaccines (PPSV).
Conjugate vaccines, such as PCV15 and PCV20, link a part of the bacteria’s sugar coating to a protein, which creates a stronger and longer-lasting immune response, especially in children. The Centers for Disease Control and Prevention (CDC) recommends PCV for all infants and young children, as well as for adults aged 65 or older. Polysaccharide vaccines, like PPSV23, contain only the sugar coating of 23 different types of the bacteria.
PPSV23 is often recommended for adults over 65, and for individuals aged 2 through 64 who have specific chronic medical conditions that increase their risk for pneumococcal disease. Since each type of vaccine works differently, the specific vaccination schedule will be tailored by a healthcare provider. The difference in the vaccines’ composition can result in slight variations in the side effect profile.
Expected and Temporary Side Effects
The most common reactions following a pneumococcal shot are generally mild and indicate that the immune system is beginning to build protection. These reactions are typically short-lived, resolving within one to three days after the injection. These normal responses can be divided into two categories: local reactions at the injection site and systemic reactions affecting the whole body.
Local reactions occur where the shot was administered, usually the arm or leg. These reactions can include pain, tenderness, redness, or swelling at the injection site. Approximately 50% of recipients experience a local reaction. The soreness is due to the immune cells rushing to the area to process the vaccine.
Systemic reactions are felt throughout the body and are also temporary. These can include a low-grade fever, fatigue, muscle aches, headache, and a general feeling of being unwell or malaise. Children may also exhibit increased irritability, drowsiness, or a temporary loss of appetite. These symptoms are a natural part of the immune response.
A fever higher than 100.4°F occurs in about one out of every three infants who receive a PCV shot. The temporary nature of these symptoms distinguishes them from an actual infection. While uncomfortable, the presence of these expected side effects confirms the vaccine is working to establish immunity.
Rare and Severe Reactions and When to Seek Medical Attention
Recipients should be aware of rare, severe reactions and know when to seek professional medical attention. Managing common symptoms can often be done at home with over-the-counter medication. Acetaminophen or ibuprofen can be used to alleviate fever and muscle aches, and applying a cool compress to the injection site can help reduce swelling and discomfort.
Severe allergic reactions, known as anaphylaxis, are extremely rare, occurring in approximately one in a million doses. Anaphylaxis is a life-threatening emergency that typically develops within minutes to a few hours after vaccination. Signs of a severe allergic reaction include hives, swelling of the face or throat, wheezing, or difficulty breathing.
Another rare reaction is syncope, or fainting, which can sometimes occur immediately following any injection. Although not a direct vaccine side effect, a person who feels faint or dizzy should be monitored to prevent injury from a fall. Recipients should remain seated for a period after the shot to minimize this risk.
A healthcare provider should be contacted if a local reaction is severe, or if it worsens more than 48 hours after the injection. Medical attention is also warranted for a high fever, such as one persisting beyond 24 hours or rising above 105°F. If any signs of anaphylaxis appear, emergency services should be called immediately.

