Lignosus rhinocerotis, commonly known as Tiger Milk Mushroom, is a medicinal fungus historically used across Southeast Asia. The sclerotium, a hardened mass of fungal mycelium, has long been employed as a traditional remedy and general health tonic. Traditional applications primarily focus on respiratory ailments, such as cough and asthma, and promoting overall well-being. While generally regarded as safe, understanding the safety profile of this supplement is important.
Mild and Temporary Adverse Reactions
The most frequent issues reported by new users involve the digestive system. These reactions are typically mild, self-limiting, and often occur as the body adjusts to the supplement. Gastrointestinal distress, including mild diarrhea, bloating, and gas, can be experienced, particularly when initiating use or when the dosage is higher than recommended.
This discomfort is sometimes attributed to the mushroom’s high fiber content, which can temporarily alter gut motility. Some individuals may also report a feeling of “heatiness,” referring to symptoms like a dry mouth or tongue. Reducing the intake or gradually increasing the dose generally resolves these initial symptoms.
A temporary increase in phlegm is also occasionally noted, which some consider a natural response as the body clears the respiratory tract. Other transient effects can include mild headaches or a temporary feeling of malaise. These minor adverse reactions are usually short-lived, resolving within a few days or weeks.
Serious Adverse Events and Allergic Responses
While the overall safety record for Lignosus is high, rare but more serious reactions can occur, primarily hypersensitivity. A severe allergic response is possible in individuals sensitive to mycobacterial bioproteins or other fungal components. Signs of a serious allergic reaction may include difficulty breathing, swelling of the face, lips, or throat, and persistent skin rashes or hives.
Any sign of a severe allergic reaction, such as respiratory constriction or significant swelling, requires immediate medical attention. Persistent, severe symptoms should also be treated with caution. Symptoms like severe abdominal pain, jaundice, or dark urine necessitate prompt consultation with a healthcare provider to rule out organ involvement.
Drug Interactions and Populations to Avoid
Lignosus may interact with certain types of medication due to its biological activity. The mushroom contains compounds that exhibit anti-coagulation properties, potentially enhancing the effects of blood-thinning medications like warfarin or aspirin. Combining Lignosus with these drugs increases the risk of bruising or bleeding, making medical guidance necessary.
Because the mushroom has immune-modulating effects, caution is warranted for individuals taking immunosuppressant drugs, such as those prescribed after an organ transplant or for autoimmune disorders. This influence may counteract the intended effect of these medications. Due to a lack of specific safety data, Lignosus is not recommended for pregnant or breastfeeding women.
Children should only take Lignosus under the guidance of a physician. Individuals with pre-existing conditions like acute tonsillitis or active mouth ulcers may also experience mucosal irritation and should temporarily discontinue use until those conditions resolve.
Understanding Product Quality and Safety
Product quality is a major factor in determining the safety profile and likelihood of adverse effects. Supplements derived from unregulated sources carry a significant risk of contamination. Wild-harvested or poorly cultivated mushrooms may absorb heavy metals or pesticides, which can lead to adverse health outcomes.
Dosage variability is another concern, as the concentration of active ingredients can differ greatly between products (e.g., sclerotium powder versus mycelium extract). Exceeding the recommended dosage increases the risk of experiencing mild gastrointestinal side effects. Consumers should prioritize purchasing products from reputable manufacturers that provide third-party testing results.
These tests confirm the absence of contaminants and verify the standardization of active ingredients, offering assurance of purity and consistency. Choosing a standardized product ensures that the benefits and risks align more closely with established safety data, reducing the chances of unexpected adverse reactions.

