Cataract surgery is one of the most frequently performed and successful procedures worldwide, offering millions restored vision. Although the operation is quick and highly effective, the period immediately following surgery is when the eye is most vulnerable. A precise regimen of post-operative eye drops is required for a safe and successful recovery. These drops manage inflammation and prevent infection, the two primary risks to the healing eye. Adhering strictly to your surgeon’s instructions regarding the type, dosage, and timing is crucial.
Essential Prescription Drops
The immediate post-operative phase requires two main categories of prescription drops, both playing distinct roles in safeguarding the eye. Antibiotic drops prevent endophthalmitis, a serious, though rare, infection inside the eye. Surgeons commonly prescribe a fluoroquinolone-class antibiotic, such as moxifloxacin, to be used multiple times daily, typically for the first one to two weeks following the procedure.
The second category includes anti-inflammatory drops, divided into two types: corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs). Corticosteroids, such as prednisolone, manage the inflammation and swelling that naturally occur after surgery. If left unchecked, this inflammation can slow the healing process and cause discomfort. The steroid dosage is usually tapered, meaning the frequency of use decreases over three to six weeks as the eye heals.
NSAID drops, like ketorolac or bromfenac, are often used in conjunction with steroids to provide further inflammation and pain control. They also serve the important function of reducing the risk of a complication known as cystoid macular edema, which is swelling in the retina that can temporarily blur vision. To ensure each medication is fully absorbed and not diluted by the next, it is important to observe a “drop holiday” by waiting at least five minutes between applying different types of drops. Following this exact schedule ensures the maximum therapeutic benefit from each prescription medication.
Guidelines for Over-the-Counter Lubricants
Many patients experience temporary dryness, irritation, or a gritty sensation after cataract surgery, often due to surgical incisions and temporary disruption of the tear film. Over-the-counter artificial tears, or lubricant drops, are highly recommended to soothe these symptoms and promote comfort. These drops supplement the eye’s natural moisture layer without introducing medicinal agents. They can be used as frequently as needed throughout the day for relief.
The most important distinction when selecting an over-the-counter lubricant is choosing a preservative-free formulation. Multi-dose bottles of artificial tears contain chemical preservatives to prevent bacterial growth once the bottle is opened. However, these preservatives can be irritating or toxic to the sensitive, healing ocular surface, especially with frequent use. Preservative-free drops, which typically come in small, single-use vials, eliminate this risk of irritation.
While these comfort drops are safe, they must be used correctly in relation to your medicated drops. Wait at least 15 minutes after administering any prescription drops before using an artificial tear. This waiting period prevents the lubricant from washing away the prescription medicine before it has a chance to be absorbed into the eye tissue. Always check the label to ensure the product is purely a lubricant and contains no other active ingredients.
Drops and Ingredients to Strictly Avoid
Certain over-the-counter eye drops and ingredients are strictly contraindicated following cataract surgery because they can be detrimental to healing. Chief among these are redness-relieving drops, which contain vasoconstrictor chemicals like naphazoline or tetrahydrozoline. These decongestant ingredients constrict blood vessels on the surface of the eye to temporarily reduce visible redness. Using these products can be dangerous as they may mask a serious underlying issue, such as an infection or significant inflammation.
Furthermore, these decongestants can cause a rebound effect, where the eye becomes even redder once the drop wears off, potentially leading to chronic irritation. Other products, such as contact lens cleaning or rewetting solutions, are not formulated for use on a healing eye and should never be used as an eye drop substitute. Only use the specific prescription drops provided by your surgeon and the preservative-free artificial tears you have been instructed to use.
Maintaining sterility is a final safety practice for all drops entering the eye. Never let the tip of any eye drop bottle touch your eye, eyelid, lashes, or any other surface. Contact can introduce bacteria into the solution, which could then be transferred into the vulnerable post-operative eye. Always wash your hands before handling the bottles, and discard any drops that have passed their expiration date or have been open for an extended period.

