If a female takes BlueChew, the active ingredients (sildenafil or tadalafil) will increase blood flow to genital tissue, potentially causing clitoral engorgement, increased sensitivity, and improved vaginal lubrication. The effects are real but significantly milder than what men experience, and neither ingredient is FDA-approved for use in women. BlueChew is marketed and prescribed exclusively for men with erectile dysfunction, so a woman taking it would be using it entirely off-label.
How It Works in Female Bodies
BlueChew contains the same active ingredients found in Viagra (sildenafil) or Cialis (tadalafil). These drugs work by relaxing smooth muscle and increasing blood flow. In men, that means blood flow to the penis. In women, the same enzyme these drugs target exists in the clitoris, labia, and vaginal walls, just in lower concentrations. When a woman takes one of these medications, blood flow to those tissues increases, which can lead to clitoral engorgement, heightened genital sensation, and more natural lubrication from increased fluid passing through vaginal blood vessels.
The effect is less dramatic than it is for men. Women have a lower concentration of the specific enzyme these drugs act on in their genital tissue compared to penile tissue. That biological difference is the main reason these medications haven’t been approved for women: the response is less consistent and less pronounced.
What Clinical Trials Actually Found
Researchers have studied sildenafil in women, most notably in a 12-week, double-blind, placebo-controlled trial of 202 postmenopausal women with sexual arousal disorder. Women who took sildenafil (starting at 50 mg, adjustable to 25 or 100 mg) reported significantly greater genital sensation during stimulation and greater satisfaction with sexual activity compared to women on placebo.
The results were strongest for women whose primary issue was physical arousal rather than low desire. Among women who had arousal problems without also having low libido, the improvements were striking: they were about four times more likely to report better lubrication, over four times more likely to achieve orgasm, and roughly eleven times more likely to rate their overall sexual experience as improved compared to placebo. For women whose main problem was low desire, sildenafil showed no significant benefit. This makes sense: the drug increases blood flow, but it doesn’t create desire. It works on plumbing, not motivation.
A separate MRI study used 100 mg sildenafil to measure clitoral engorgement in premenopausal women with arousal disorder, confirming that the drug does physically increase blood flow to the clitoris in a measurable way.
Side Effects to Expect
Women in clinical trials experienced the same side effects men typically report. The most common were headache, facial flushing, nasal congestion, nausea, and visual disturbances (such as a temporary blue tint to vision or increased light sensitivity). Most side effects were mild to moderate.
The more serious risk applies equally to both sexes: these drugs cause a dangerous drop in blood pressure when combined with nitrate medications, which are commonly prescribed for chest pain. That includes nitroglycerin patches and tablets. Studies have shown large, sudden decreases in blood pressure in the majority of patients who combined the two. Women taking nitrates should not take BlueChew under any circumstances. The same applies to anyone with very low blood pressure or certain heart conditions.
Why It Differs From Female-Specific Medications
Two medications are actually FDA-approved for low sexual desire in premenopausal women: flibanserin (Addyi) and bremelanotide (Vyleesi). These work in a completely different way. While BlueChew’s ingredients increase blood flow to genitals, flibanserin acts on brain chemistry by boosting dopamine and norepinephrine while lowering serotonin in areas of the brain that regulate sexuality. It’s taken daily, unlike sildenafil or tadalafil, which are taken before sex.
This distinction matters. If a woman’s difficulty is primarily physical arousal (reduced sensation, dryness), increased blood flow could theoretically help. If the issue is low desire or lack of interest, a blood flow drug won’t address the underlying problem. The clinical trial data bears this out clearly: women with low desire saw no benefit from sildenafil.
Pregnancy and Breastfeeding Considerations
Sildenafil is sometimes prescribed to women for pulmonary arterial hypertension, a serious condition involving high blood pressure in the lungs. In that context, the NHS advises women who become pregnant while taking sildenafil to continue the medication because the risks of untreated pulmonary hypertension outweigh the drug risks. Only tiny amounts pass into breast milk, and it’s generally considered safe during breastfeeding when medically prescribed for that condition.
That said, there is no established safety profile for recreational or off-label sexual use of these drugs during pregnancy. The research on sildenafil in pregnant women relates specifically to a life-threatening condition managed by specialists, not to sexual enhancement.
The Practical Bottom Line
A woman who takes BlueChew will likely notice some physical effects: warmth or flushing, possibly increased genital sensitivity and lubrication. She may also get a headache or stuffy nose. The drug won’t be dangerous for most healthy women at standard doses, but it also won’t deliver the reliable, obvious results men experience. The lower concentration of the target enzyme in female genital tissue means the response is weaker and less predictable.
Neither sildenafil nor tadalafil is FDA-indicated for women. The FDA label for tadalafil states explicitly: “CIALIS is not indicated for use in women.” Because BlueChew prescriptions are written through telemedicine for male patients, a woman using someone else’s prescription also bypasses the medical screening that would catch dangerous drug interactions, particularly with nitrates or blood pressure medications.