NOVOS is a longevity supplement company founded in 2018 that sells products designed to target biological aging. The company describes itself as a “science-first longevity biotechnology company” and has built its brand around the idea that aging is a biological process that can be measured and slowed. Its main products are powdered and capsule supplements containing combinations of compounds linked to aging research, with prices ranging from about $32 to $98 per month on subscription plans.
The Company Behind the Supplements
NOVOS Labs was established with the goal of translating aging research into consumer products. The company frames its mission around “healthspan,” the number of years you live in good health, not just total lifespan. All of its products are manufactured in the United States in GMP-certified facilities, a standard quality certification for supplement production.
The company has assembled a scientific advisory board that includes researchers from Harvard Medical School, MIT, the Salk Institute for Biological Studies, and USC School of Medicine. Notable names include George Church, a well-known geneticist at Harvard, and Matt Kaeberlein, a prominent aging researcher who has worked at MIT and the University of Washington. Having recognized scientists attached to a supplement brand is relatively unusual in the industry, though advisory roles don’t necessarily mean those scientists designed or endorse every product claim.
NOVOS Core: The Flagship Product
NOVOS Core is the company’s primary supplement, a flavored powder you mix into water. Each 15-gram serving contains 12 bioactive compounds that NOVOS selected based on their connections to various aging pathways. The full ingredient list, verified through the NIH’s Dietary Supplement Label Database, includes:
- Glycine (2,000 mg): An amino acid involved in collagen production and cellular repair
- Magnesium malate (1,700 mg): A form of magnesium tied to energy production and muscle function
- Glucosamine sulfate (1,000 mg): Commonly used for joint health, but NOVOS highlights its broader cellular effects
- Rhodiola rosea extract (300 mg): An adaptogenic herb linked to stress resilience
- Calcium alpha-ketoglutarate (231 mg): A compound studied in animal models for its effects on biological age
- L-theanine (150 mg): An amino acid found in tea that promotes calm focus
- Vitamin C (100 mg): An antioxidant with roles in immune function and collagen synthesis
- Hyaluronic acid (100 mg): A molecule that helps tissues retain moisture, commonly associated with skin health
- Fisetin (100 mg): A plant compound being researched for its ability to clear damaged, aging cells
- Ginger root extract (100 mg): Standardized to contain gingerols, which have anti-inflammatory properties
- Pterostilbene (50 mg): A compound similar to resveratrol but more easily absorbed by the body
- Micro-dose lithium (1 mg): A trace mineral that some research links to neuroprotection at very low doses
The logic behind Core is that aging involves multiple biological processes happening simultaneously, so a single ingredient won’t meaningfully help. The formulation attempts to address several of these processes at once. A clinical trial covered by Medical News Today found that NOVOS Core improved markers of vascular aging, though this is a relatively narrow finding compared to the broader anti-aging claims the product carries.
NOVOS Boost and Other Products
NOVOS Boost is a simpler product containing a single ingredient: NMN (nicotinamide mononucleotide) at greater than 99% purity, verified by independent third-party testing. NMN is a precursor to NAD+, a molecule your cells use for energy production and DNA repair. NAD+ levels decline with age, and NMN supplementation aims to restore them. The small amount of impurities in NOVOS Boost consists only of nicotinamide, NR, and water.
The company also sells NOVOS Vital, a newer addition to the lineup, and offers a biological age test called NOVOS Age. For customers who want everything, there’s a Longevity Kit bundle that includes Core, Boost, and the age test.
What It Costs
NOVOS products sit at the premium end of the supplement market. Shipping is free on all orders. Here’s how pricing breaks down depending on your commitment level:
NOVOS Core runs $109 as a one-time purchase, drops to $98 per month with a monthly subscription, and falls to $79 per month if you pay for a full year upfront ($950 total). NOVOS Boost ranges from $44 one-time to $32 per month on an annual plan ($385 upfront). NOVOS Vital falls between the two, from $69 one-time to $49 per month annually ($599 upfront).
If you subscribe to both Core and Boost monthly, you’re looking at roughly $130 to $140 per month depending on your plan. The all-in Longevity Kit, which bundles Core, Boost, and the biological age test, costs $2,273 one-time or $1,684 on subscription. These prices make NOVOS significantly more expensive than mainstream multivitamins, though the company positions itself as a different category entirely.
What the Science Actually Supports
Most of the individual ingredients in NOVOS Core have some research backing, but context matters. Many of the studies were conducted in animals, in cell cultures, or at dosages different from what NOVOS uses. Fisetin, for example, has shown promise as a senolytic (a compound that clears damaged cells) in mouse studies, but large-scale human trials are still limited. NMN has stronger human data, with several small clinical trials showing improvements in markers like NAD+ levels and insulin sensitivity, though long-term outcomes remain unclear.
The clinical trial on the full NOVOS Core formulation showing improvements in vascular aging markers is a meaningful step beyond what most supplement companies offer, where individual ingredient studies are cited but the actual combined product is never tested. Still, vascular aging markers are a surrogate endpoint. They suggest something positive may be happening in blood vessels, but they don’t prove the supplement extends lifespan or prevents specific diseases.
The fundamental challenge with any longevity supplement is that proving it works requires decades of follow-up. No supplement currently on the market has been shown in a rigorous, long-term human trial to extend lifespan. NOVOS is transparent about leaning on the best available evidence, but “best available” in a young field still leaves significant uncertainty. The product is a bet on promising early science, not a proven intervention.