PPE in healthcare stands for personal protective equipment, the clothing and gear that creates a physical barrier between healthcare workers and infectious materials like blood, body fluids, and respiratory secretions. It includes gloves, gowns, masks, respirators, face shields, and goggles. Beyond protecting the worker, PPE also shields vulnerable patients (those with weakened immune systems or undergoing surgery) from germs that visitors or staff might carry in.
Core Types of Healthcare PPE
Each piece of PPE targets a specific route of exposure. Together, they cover the main ways infections spread in clinical settings.
- Gloves protect hands during any contact with blood, body fluids, mucous membranes, or contaminated surfaces. They’re the most frequently used piece of PPE and must be changed between patients, between contaminated and clean body sites on the same patient, and whenever a hand hygiene opportunity arises.
- Gowns cover exposed skin and clothing during procedures or patient interactions likely to generate splashes or direct contact with infectious material. Gowns are rated on a four-level scale. Levels 1 through 3 offer increasing water resistance but are only tested against water, not blood. Level 4 gowns are the only ones tested and rated for resistance to blood and viral penetration, making them the standard for high-risk procedures like surgery involving large volumes of fluid.
- Surgical masks block large respiratory droplets from reaching the nose and mouth. They come in three ASTM levels: Level 1 filters at least 95% of bacteria and resists fluid at 80 mmHg of pressure, suitable for low-risk exams. Levels 2 and 3 both filter at least 98% of bacteria and sub-micron particles, with Level 3 offering the highest fluid resistance at 160 mmHg, designed for procedures where significant spray or splatter is expected.
- N95 respirators seal tightly to the face and filter at least 95% of very small airborne particles. They’re required when caring for patients with airborne infections like tuberculosis or measles. OSHA mandates that every healthcare worker using an N95 be fit-tested before first use, any time they switch to a different model or size, and at least once a year after that.
- Eye protection (goggles or face shields) covers the mucous membranes of the eyes, which can absorb infectious droplets. Face shields offer broader coverage, protecting the entire face from splashes during procedures.
How PPE Changes by Infection Type
Healthcare facilities don’t use one standard set of PPE for every patient. The combination depends on how an infection spreads, and the CDC groups these into three categories of transmission-based precautions.
Contact precautions apply to infections spread by direct or indirect touch, such as MRSA or C. diff. The required PPE is a gown and gloves for all interactions that might involve contact with the patient or their immediate environment.
Droplet precautions cover illnesses transmitted through larger respiratory droplets that travel short distances, like influenza or bacterial meningitis. A mask goes on before entering the patient’s room.
Airborne precautions are for pathogens that float in tiny particles over long distances, like tuberculosis. These require a fit-tested N95 respirator or higher-level device, and the patient is placed in a special negative-pressure room that prevents contaminated air from drifting into the hallway.
In practice, many situations call for combining elements. A patient with a novel respiratory virus might require airborne precautions plus contact precautions, meaning an N95, eye protection, gown, and gloves all at once.
Putting PPE On and Taking It Off Safely
The order in which you put on (don) and remove (doff) PPE matters because the outer surfaces become contaminated during patient care. Removing gear in the wrong sequence can transfer pathogens to your skin, scrubs, or face.
The CDC’s recommended donning sequence generally starts with the gown, then the mask or respirator, then eye protection, and finally gloves. Gloves go on last so they can overlap the gown’s cuffs, sealing the gap at the wrist.
Removal is more critical and essentially reverses the logic. Gloves come off first because they’re the most contaminated. The gown follows: you unfasten the neck and waist ties, peel it away from each shoulder, and roll it inside out so the contaminated exterior is contained in a bundle. Eye protection comes off next, handled only by the headband or earpieces (the “clean” parts). The mask or respirator is last, removed by grasping only the ties or elastic bands, never the front surface. Hand hygiene happens immediately after every piece is removed and is essential once all PPE is off.
Gloves Don’t Replace Hand Washing
One of the most common misconceptions in healthcare settings is that wearing gloves eliminates the need for hand hygiene. The World Health Organization is explicit on this point: glove use never replaces hand washing or the use of alcohol-based hand rub. You clean your hands before putting gloves on and again after taking them off. If a hand hygiene moment comes up while you’re already gloved, the gloves come off, you wash or sanitize, and you put on a fresh pair.
Gloves also need to be changed during care of a single patient when moving from a contaminated body site to a cleaner one, or when touching a medical device. Using the same pair of gloves throughout an entire encounter can spread bacteria from one site to another.
Employer Responsibilities
Under OSHA regulations, healthcare employers are required to provide PPE at no cost to workers. Employers cannot ask staff to supply their own equipment, and if a worker happens to own PPE and chooses to use it voluntarily, the employer still has to verify that it meets workplace safety standards. Employers are also responsible for training staff on proper use, care, and limitations of every type of PPE they may need. Workers, in turn, are expected to attend those training sessions and use the equipment as directed.
Reusable vs. Disposable PPE
Most PPE in healthcare today is single-use and disposable, especially gloves, surgical masks, and N95 respirators. Some gowns and face shields, however, are designed for reprocessing and reuse. The question of whether reusable PPE is better than disposable alternatives doesn’t have a clear answer yet. No strong data establishes that one approach is safer than the other from an infection-control standpoint. What is increasingly discussed is the environmental cost: healthcare generates enormous volumes of plastic waste from disposable equipment, and the tradeoff between a small, unquantified infection-control risk and the environmental and human health burden of single-use products is an active area of evaluation.

