Systemic Multi Enzyme Therapy (SMET) involves the oral administration of specific enzyme combinations, primarily proteolytic enzymes, designed to be absorbed into the bloodstream. Unlike digestive enzymes, which act locally in the gastrointestinal tract to break down food, SMET utilizes enzymes that enter the systemic circulation to exert effects throughout the entire body. The goal of this therapy is to support the body’s natural regulatory and healing processes by influencing inflammation, tissue repair, and circulatory health. This method has a history of use in central Europe and Japan, where it was developed to address various inflammatory conditions and support recovery.
The Specific Enzymes Used
Systemic Multi Enzyme Therapy formulations are characterized by a combination of enzymes, with a strong focus on proteases, which are enzymes that break down proteins. Two of the most commonly used plant-derived proteases are bromelain, sourced from the pineapple stem, and papain, which is extracted from the papaya fruit. These enzymes break down peptide bonds in proteins, allowing them to exert systemic effects once absorbed.
Animal-derived enzymes are also frequently included, notably pancreatin, which is a mixture of pancreatic enzymes containing trypsin and chymotrypsin. These enzymes contribute significant proteolytic activity to the blend. Some formulations also incorporate non-enzyme components, such as the bioflavonoid rutin, which is included for its antioxidant properties and its supportive role in strengthening capillary walls.
How Enzymes Work Systemically
Once the enzymes are absorbed through the intestinal wall, they enter the bloodstream and begin to interact with various physiological systems, primarily by influencing circulating proteins. One primary mechanism is fibrinolytic activity, where the enzymes assist in breaking down excess fibrin, a protein involved in blood clotting and the formation of scar tissue. Reducing this excess fibrin can improve the fluidity of blood and lymph, enhancing circulation and nutrient delivery to damaged tissues.
The enzymes also modulate the inflammatory cascade by acting on pro-inflammatory mediators, such as cytokines and bradykinin. They help to break down these compounds, optimizing the body’s response to irritation or injury without completely suppressing the initial inflammatory phase. Furthermore, systemic enzymes act as “scavengers” by helping to dismantle circulating immune complexes (CICs), which are large protein structures formed when antibodies bind to antigens. The enzymes bind to and facilitate the elimination of these complexes, which otherwise accumulate in tissues and contribute to inflammation.
Common Applications of Enzyme Therapy
Systemic Multi Enzyme Therapy is frequently utilized to support the body’s recovery from physical trauma and chronic inflammatory states. A key application is in the management of soft tissue injuries, such as sprains, strains, and contusions often sustained in sports. The enzymes help reduce swelling and bruising, which can accelerate the healing process by improving local circulation.
The therapy is also commonly employed for post-surgical recovery, where its ability to reduce inflammation and clear debris from the surgical site is beneficial. By helping to resolve swelling and pain, the enzymes support faster tissue regeneration and reduced downtime after procedures. For individuals dealing with mild inflammatory conditions, the systemic action on inflammatory proteins offers a supportive mechanism to maintain a balanced inflammatory response throughout the body, including in joints and muscles.
Proper Administration and Timing
To ensure the enzymes achieve a systemic effect rather than simply aiding digestion, proper administration is crucial. Systemic enzymes must be taken on an empty stomach so they can pass through the stomach and be absorbed into the bloodstream via the small intestine without being consumed by the process of breaking down food. This generally means taking the capsules at least 45 to 60 minutes before a meal or approximately two hours after the last meal.
Many formulations are protected by an enteric coating, a specialized barrier that prevents the enzymes from being degraded by the acidic environment of the stomach. This coating ensures that the active components are released in the small intestine, maximizing their systemic absorption. Dosage typically involves higher amounts for acute conditions, such as a recent injury or surgery, followed by a lower maintenance dose once the initial recovery phase has passed.