What Is the Success Rate of an Epidural Injection in the Neck C5-C6?

A cervical epidural injection at the C5-C6 level treats persistent neck and arm pain, often caused by cervical radiculopathy. This condition involves a compressed or irritated nerve root, leading to radiating pain, numbness, or tingling that travels down the shoulder and arm. This minimally invasive procedure is sought by individuals whose symptoms have not improved with conservative therapies, such as oral medications and physical therapy.

The Purpose of Cervical Epidural Injections

The goal of a cervical epidural injection is to alleviate pain associated with nerve root irritation, often caused by a herniated disc or spinal stenosis. The injection delivers an anti-inflammatory corticosteroid and a local anesthetic directly into the epidural space, the area surrounding the spinal cord and nerve roots. Targeting this specific location allows the medication to bathe the inflamed nerve root, reducing swelling and pressure.

The C5-C6 level is a common site for degenerative changes, such as disc issues and bone spur formation. When the disc between the fifth and sixth cervical vertebrae bulges or herniates, it typically irritates the C6 nerve root, causing symptoms that radiate into the arm. The steroid calms the inflammatory response around the compressed nerve, providing temporary pain relief. This relief allows the patient to participate more effectively in physical therapy, which is crucial for long-term recovery.

Understanding the Procedure

Patients are instructed to fast for a few hours and may need to temporarily stop taking blood-thinning medications beforehand. The patient is positioned face down, the neck area is sterilized and draped, and a local anesthetic is used to numb the injection site.

The provider uses real-time X-ray guidance, known as fluoroscopy, to ensure precise needle placement into the epidural space at C5-C6. A small amount of contrast dye is then injected to confirm the needle tip location and verify the medication will spread appropriately. This dye step is also crucial for ensuring the needle is not inadvertently positioned within a blood vessel.

Once correct placement is confirmed, the therapeutic mixture of corticosteroid and anesthetic is slowly injected. Two common approaches are used: the interlaminar approach, where the needle enters between the laminae on the back of the spine, and the transforaminal approach, which targets the side of the spine near the nerve root exit. After the injection is complete, the needle is removed, and the patient is monitored briefly before being discharged.

Success Rates and Variables Affecting Outcomes

The effectiveness of a cervical epidural injection for radiculopathy varies among individuals, but studies offer a range of expected success. For short-term pain relief (lasting weeks to a few months), approximately 40% to 84% of patients report partial improvement. Studies suggest that 50% to 70% of patients with a herniated disc may experience significant pain relief.

The duration of pain relief typically averages between three to six months, though some patients experience longer relief. Long-term outcomes, such as sustained relief beyond one year or the avoidance of surgery, are less reliably predicted by a single injection. Retrospective reviews indicate that 60% of patients maintain pain reduction at follow-up periods ranging from one to four years.

The underlying diagnosis influences the success rate, with better outcomes observed in cases of acute radiculopathy caused by a soft disc herniation compared to chronic conditions like severe spinal stenosis. The type of approach also plays a role. The transforaminal method allows for more precise medication delivery around the specific nerve root, while the interlaminar approach spreads the medication more broadly within the epidural space. Patients with pain lasting at least four to six weeks, but not excessively chronic, are often considered the best candidates for a positive response.

Safety Profile and Post-Injection Care

Cervical epidural injections are low-risk, but potential complications exist. Common minor side effects include a temporary increase in neck or nerve pain, headache, and temporary facial flushing due to the steroid. Some patients may also experience lightheadedness or a vasovagal reaction, which is a temporary fainting episode.

More serious, though extremely rare, risks include infection, bleeding, or nerve injury. The most concerning rare complications involve inadvertent injection into a blood vessel or the spinal cord, which can lead to stroke, paralysis, or other neurological deficits. The use of fluoroscopy and contrast dye helps minimize these risks by ensuring accurate needle placement.

Immediately following the injection, patients are observed for 10 to 20 minutes to monitor for any adverse reactions. Temporary numbness or weakness in the arm may occur from the local anesthetic but should resolve within a few hours. Patients are advised to avoid strenuous activity for the remainder of the day and to have someone drive them home. The full therapeutic effect of the steroid medication is not immediate and may take up to two weeks to be fully realized.