A nebulizer is a medical device that transforms liquid medicine into a fine, breathable mist, allowing the medication to be inhaled directly into the lungs. This process requires a specific liquid medium to function effectively and safely. Only a sterile saline solution should be used unless a physician directs otherwise. Using incorrect liquids can cause serious respiratory irritation, infection, or damage to the nebulizer device itself.
The Necessity of Sterile Saline Solution
The medium used in a nebulizer must closely match the natural chemistry of the respiratory system. This requirement is met by sterile isotonic saline solution, which is a 0.9% concentration of sodium chloride in water. This specific ratio creates osmotic equilibrium, meaning the solution has the same salt concentration as the fluids that naturally line the lung tissues.
Inhaling an isotonic solution prevents the irritation and adverse cellular reactions that occur with plain water. This balanced salt content avoids causing the lung lining cells to either swell or shrink. This helps prevent uncomfortable side effects like coughing or bronchoconstriction, which is a tightening of the airways. Nebulized saline primarily introduces moisture into dry airways and helps thin out thick mucus, making it easier to clear from the lungs.
The solution must be medical-grade and sterile to minimize the risk of introducing harmful pathogens directly into the lower respiratory tract. Sterile saline for inhalation is typically sold in single-use, unit-dose vials specifically labeled for use with nebulizers. These vials ensure the solution remains uncontaminated right up to the moment of use. Using a non-sterile solution, even if chemically balanced, poses a significant risk of respiratory infection because the aerosol bypasses the body’s natural filtering mechanisms.
Why Tap, Bottled, and Distilled Water Are Dangerous
Tap Water
Tap water, while safe for drinking, is non-sterile and contains various microorganisms and mineral traces that make it unsuitable for inhalation. Microorganisms like Pseudomonas aeruginosa or Legionella are often present in low levels. When nebulized, they are delivered directly into the lungs, potentially causing severe respiratory infections like pneumonia, as the respiratory system lacks the protections provided by the digestive system.
Tap water also contains dissolved minerals such as calcium and magnesium, which do not vaporize. When the water turns to mist, these minerals are left behind and inhaled as fine particulates. Inhaling these mineral deposits can cause direct irritation to the delicate lung tissues. They may also lead to a buildup that clogs the fine nozzles of the nebulizer device.
Bottled and Filtered Water
Bottled or filtered water should not be used in a nebulizer, despite appearing clean. These products are generally not required to meet the strict sterility standards necessary for inhalation into the lungs. Although filtration processes remove certain impurities, the water is not packaged in a sterile environment and can still contain viable microbial contaminants.
The mineral content in bottled water can vary widely, introducing an unknown factor into the nebulization process. Even if the water is purified, it still does not provide the necessary isotonic balance required for safe inhalation. Introducing any non-sterile, non-saline solution directly into the respiratory system bypasses the body’s natural defenses, increasing the risk of irritation and infection.
Distilled Water
Distilled water is pure water that has had its mineral and salt content removed, but this purity is precisely what makes it dangerous for nebulization. Distilled water is a hypotonic solution, meaning it has a significantly lower concentration of salt than the body’s tissues. When inhaled, this difference in concentration creates an osmotic imbalance.
The hypotonic water draws moisture out of the lung lining cells, causing them to swell and become irritated. This cellular reaction can trigger an immediate reflex known as bronchoconstriction, leading to severe coughing and wheezing. Using distilled water can increase inflammatory cell influx and oxidative stress in the lung tissue, potentially exacerbating underlying respiratory conditions.

