Fire ants are aggressive insects that deliver a painful sting, often in large numbers when their mound is disturbed. Unlike a bee, a fire ant bites to anchor itself to the skin and then pivots to inject venom multiple times with its stinger. The venom, primarily solenopsin, causes immediate pain and the characteristic localized tissue damage. This initial event creates a burning sensation at the sting site, quickly followed by a localized red welt.
Immediate First Aid for Localized Symptoms
The first action following a fire ant sting is to quickly remove the ants, as they can sting repeatedly in a semi-circular pattern. Briskly brush the ants off the skin without crushing them, and immediately move away from the disturbed mound to prevent further stings. Crushing the ants releases alarm pheromones that can attract more fire ants.
Once the immediate threat is gone, gently wash the affected skin with soap and cold water. To manage the resulting pain and swelling, apply a cold compress or an ice pack wrapped in a cloth to the area for 10- to 20-minute intervals. The cold temperature constricts blood vessels and helps limit the spread of the local reaction.
Over-the-counter medications can help alleviate common symptoms like itching and localized swelling. An oral antihistamine, such as cetirizine or loratadine, can reduce the body’s histamine response and lessen the intense itching. Topical hydrocortisone cream or a similar steroid ointment applied directly to the sting sites may also help soothe inflammation and itching. For localized pain, a non-steroidal anti-inflammatory drug (NSAID) like ibuprofen can be taken.
Recognizing and Responding to Severe Allergic Reactions
While most reactions remain localized, approximately 1% to 2% of people stung by fire ants experience a severe systemic allergic reaction known as anaphylaxis. This life-threatening condition requires immediate medical intervention, as symptoms can progress rapidly.
Signs of a severe reaction include difficulty breathing, wheezing, or tightness in the throat, which indicates swelling of the airways. Other systemic symptoms can involve swelling of the tongue or face, generalized hives or itching that spreads away from the sting site, and dizziness or fainting. Nausea, vomiting, or stomach cramps are also possible signs of a widespread allergic response.
Immediately call emergency services. Individuals with a known insect allergy should carry a prescribed epinephrine auto-injector and use it without delay. Administering epinephrine quickly can reverse the effects of anaphylaxis, but the patient must still be transported to an emergency room for observation.
Managing Pustules and Preventing Secondary Infection
The fire ant sting causes the formation of a sterile, fluid-filled pustule, or blister, at the site of each sting. While they may resemble pimples, they are not filled with pus from a bacterial infection but are instead a unique inflammatory response.
The most important step in the days following the sting is to leave these pustules intact. Breaking or scratching the blister compromises the skin barrier, turning the sterile site into an open wound susceptible to bacterial infection. Avoid the temptation to pop or drain the fluid, as this increases the risk of complications and potential scarring.
Keep the area clean and dry, and continue to manage itching with topical creams or oral antihistamines to prevent scratching. If a pustule does break accidentally, gently clean the area with soap and water and apply an over-the-counter antibiotic ointment. Monitor the site for signs of a secondary bacterial infection, such as increasing redness, warmth spreading from the sting site, swelling, or a fever. If these signs appear, medical attention is necessary, as oral antibiotics may be required to resolve the infection.

