A bee sting occurs when a honeybee injects venom through its barbed stinger, causing an immediate, painful reaction. The venom contains proteins that trigger a localized inflammatory response. For most people, the reaction is mild and resolves with basic home care. Antibiotics treat bacterial infections, not the chemical inflammation caused by venom, so they are generally not necessary for a typical sting reaction. They are reserved only for rare instances where a secondary bacterial infection develops at the sting site.
Immediate Care for Bee Stings
The first step after a honeybee sting is to remove the stinger quickly, since the venom sac remains attached and continues to pump venom into the skin for up to a minute. Scraping the stinger out with a fingernail or a credit card is often recommended to avoid squeezing the venom sac. After removal, the area should be thoroughly cleaned with soap and water to minimize the risk of introducing bacteria into the puncture wound.
Following stinger removal and cleaning, managing the initial pain and swelling is the focus. Applying a cold compress or ice pack wrapped in a cloth helps reduce inflammation and discomfort. Over-the-counter pain relievers, such as ibuprofen or acetaminophen, can be taken to manage the pain.
Antihistamines, either oral or topical, may be used to help control itching and localized swelling caused by the venom. Most people experience a mild reaction, characterized by temporary pain and swelling that lasts a few hours. Moderate swelling and redness can worsen over the first 24 to 48 hours and may last up to seven days, but this remains a non-infectious venom reaction.
Recognizing Secondary Bacterial Infection
It is important to distinguish between the expected inflammatory response to venom and a true secondary bacterial infection. The normal reaction involves redness, swelling, and warmth that typically peaks within a day or two and then begins to improve. This reaction does not require antibiotics.
A secondary bacterial infection, such as cellulitis, usually appears 24 hours or more after the sting. These infections occur when bacteria, often introduced through scratching, enter the wound site. Key indicators include symptoms that worsen dramatically after the first day or two instead of improving.
Specific signs of a bacterial infection include pain that significantly increases after 24 hours, or redness that spreads rapidly in streaks away from the sting site. The presence of pus or thick, cloudy drainage is a strong indication of bacterial activity. Systemic symptoms, such as a fever above 100.4°F (38°C) or chills, signal that the infection has spread beyond the immediate area.
The risk of infection increases if the sting site is scratched or if initial wound care was inadequate. Scratching breaks the skin barrier, allowing bacteria like Staphylococcus or Streptococcus species to penetrate deeper tissue. Monitoring the sting site for progressive symptoms is the most reliable way to identify this uncommon complication.
When Antibiotics Are Necessary
Antibiotics become necessary only when a healthcare provider confirms a secondary bacterial infection at the sting site. The medication works by targeting the specific bacteria, not by neutralizing the bee venom. A doctor will assess the severity and extent of the infection before determining the appropriate treatment.
For localized infections, a doctor may prescribe a topical antibiotic ointment. If the infection is more widespread, characterized by spreading redness (cellulitis) or systemic symptoms like fever, an oral antibiotic is required. These medications are chosen to target the most likely culprits, such as Staphylococcus aureus and Streptococcus pyogenes.
The duration of antibiotic treatment for uncomplicated cellulitis is often a five-to-six-day course. It is important to complete the entire course of medication as prescribed, even if symptoms begin to improve quickly. Only a medical professional can determine if antibiotics are warranted, based on the patient’s symptoms and the progression of the wound.

