Dicyclomine (Bentyl) is a prescription medication used to manage issues within the digestive tract. It belongs to a class of anticholinergics and antispasmodics that influence muscle activity. This medication is prescribed to address discomfort and abnormal movements in the stomach and intestines, providing symptomatic relief for recurring gastrointestinal problems involving muscle spasms.
The Purpose of Dicyclomine
Dicyclomine relieves discomfort associated with involuntary muscle contractions in the gut. It acts through a dual mechanism to relax the smooth muscles lining the stomach and intestines. One action involves blocking acetylcholine, a chemical messenger that signals muscles to contract. This anticholinergic effect reduces the strength of muscle spasms that cause sharp, colicky pain.
The drug also exerts a direct relaxant effect on the smooth muscle tissue, independent of nerve signaling. This combined action helps diminish symptoms such as abdominal cramping, bloating, and excessive gas that occur with conditions like Irritable Bowel Syndrome. By slowing the movements of the gastrointestinal tract, dicyclomine helps restore a more comfortable rhythm and improve overall patient comfort.
Proper Timing and Administration
Dicyclomine is typically prescribed as an oral dose taken four times throughout the day. This frequent dosing schedule is necessary because the medication’s duration of action is relatively short. To achieve maximum benefit, it is recommended to take the drug approximately 30 to 60 minutes before meals. Taking the medication before eating allows the active ingredients to be absorbed and reach therapeutic levels by the time digestion begins.
This timing ensures the muscle-relaxing effects are present when the gastrointestinal tract is most likely to be stimulated and prone to spasms. Symptom relief usually begins within one to one and a half hours after an oral dose. Consistency is important for managing chronic symptoms, and the exact dosage must be determined and adjusted by a healthcare provider.
If a dose is missed, take it as soon as it is remembered, unless it is close to the time for the next scheduled dose. In that case, skip the missed dose entirely and continue with the regular schedule. Never take a double dose to make up for a missed one, as this increases the risk of side effects.
Situations Requiring Caution
Dicyclomine’s anticholinergic properties mean it is not safe for everyone and requires specific precautions. The drug can exacerbate certain pre-existing medical conditions, making its use contraindicated in several situations. For example, individuals with narrow-angle glaucoma should not take dicyclomine because it can increase pressure within the eye.
The medication is also prohibited for people with obstructive diseases of the urinary or gastrointestinal tract, such as paralytic ileus or toxic megacolon. Since dicyclomine relaxes smooth muscles, it can worsen or cause a dangerous blockage in these patients. Other contraindications include myasthenia gravis, severe ulcerative colitis, and unstable cardiovascular status during acute hemorrhage.
Patients must also be aware of potential drug interactions, especially with other medications that have anticholinergic effects. Combining dicyclomine with certain antihistamines, tricyclic antidepressants, or other antispasmodics can intensify side effects like dry mouth, blurred vision, and drowsiness. Antacids should not be taken at the same time as dicyclomine, as they can interfere with proper absorption.
Dicyclomine can cause side effects such as blurred vision, dizziness, and drowsiness, which impact mental alertness. Patients should determine how the medication affects them before engaging in activities requiring full concentration, such as driving or operating heavy machinery. Furthermore, the drug decreases the body’s ability to sweat, increasing the risk of heat exhaustion or heat stroke during hot weather or strenuous exercise.

