An electrocardiogram (ECG) is a non-invasive diagnostic tool that records the small voltage changes generated by the heart’s electrical activity. These electrical signals are captured by electrodes placed on the body surface, which are then translated into wave patterns on a tracing. The concept of “leads” refers to the specific electrical viewpoints or angles from which the heart’s activity is being observed. Because the heart is a three-dimensional organ, using multiple leads allows clinicians to map the electrical current across the heart’s entire surface. This system provides spatial information, recording activity along three orthogonal directions: right-to-left, superior-to-inferior, and anterior-to-posterior.
The Specific Anterior Leads
The leads that specifically capture the electrical activity of the heart’s anterior surface are part of the larger group known as the precordial leads, which are designated V1 through V6. The anterior viewing leads are V1, V2, V3, and V4, which are positioned directly over the front of the chest. These leads are typically subdivided based on the specific areas of the heart’s ventricular muscle they observe. Leads V1 and V2 are often described as the anteroseptal leads because they primarily record electrical activity from the interventricular septum, the muscular wall separating the two lower chambers of the heart. The septum is the first part of the ventricles to depolarize, or contract electrically. Leads V3 and V4 are considered the true anterior leads, as their placement offers a direct view of the large anterior wall of the left ventricle. This grouping allows for a nuanced assessment of electrical flow across the entire front surface of the heart.
Anatomical Placement of Precordial Leads
The accurate placement of the precordial leads is necessary for obtaining a correct electrical map of the heart. These electrode positions are defined using specific external anatomical landmarks on the chest wall. Placement involves identifying the sternal angle, a slight ridge on the breastbone that corresponds to the second rib.
- V1 is placed in the fourth intercostal space along the right border of the sternum.
- V2 is positioned in the fourth intercostal space along the left border of the sternum.
- V4 is positioned in the fifth intercostal space at the mid-clavicular line.
- V3 is placed midway between the V2 and V4 electrodes.
This precise arrangement ensures that the electrical views of the heart are standardized for accurate interpretation.
Detecting Changes in the Anterior Wall
Monitoring the anterior leads is clinically significant because changes in the electrical tracing can indicate damage to the underlying heart muscle, most often the anterior wall of the left ventricle. This area is supplied by the left anterior descending (LAD) coronary artery, and its occlusion is a common cause of heart attacks. When heart muscle cells suffer from a lack of blood flow (ischemia) or die (infarction), they generate abnormal electrical currents that are visible on the ECG.
The most concerning finding in these leads is ST-segment elevation, which suggests an acute injury and is the hallmark of an ST-Elevation Myocardial Infarction (STEMI). The ST segment is the flat line between the QRS complex and the T wave, and its elevation indicates that a large area of tissue is severely compromised. For a diagnosis of acute injury, this elevation must be present in at least two adjacent or contiguous leads, such as V2 and V3.
Other abnormal findings include T-wave inversions, which signify ischemia or reduced blood flow, and the development of pathological Q waves. Pathological Q waves are deeper and wider than normal, indicating that a segment of the anterior wall has already sustained irreversible damage and formed a scar.

