The application of an antiseptic solution inside the nose is a standard, yet often puzzling, step in modern pre-surgical preparation. While it may seem unusual to focus on the nostrils when the surgery is elsewhere on the body, this procedure is a calculated effort to manage one of the biggest risks in a hospital setting: infection. This practice is part of a comprehensive strategy aimed at reducing the risk of infection and ensuring the safest possible outcome for the patient.
The Primary Goal: Preventing Surgical Site Infections
The main reason for nasal antiseptic application is to significantly lower the risk of Surgical Site Infections (SSIs). An SSI is an infection that occurs in the part of the body where the surgery took place, ranging from a superficial skin infection to one involving deep tissues and organs. These infections are a major concern in healthcare, as they can lead to a prolonged recovery period, additional medical treatments, and a substantial increase in hospital costs. Preventing SSIs is a top priority because the patient’s own body is often the source of the bacteria that cause the infection. Although surgical teams rigorously sterilize instruments and the operating room environment, they must also minimize exposure to the patient-borne bacteria that naturally live on the skin and mucous membranes.
The Source of the Problem: Nasal Bacteria Reservoirs
The nose is a common and high-density reservoir for numerous types of bacteria, even in perfectly healthy individuals. The moist environment of the anterior nares, or the front part of the nostrils, makes it an ideal location for microbes to colonize. For many patients, the bacteria present in their nose can migrate to the incision site, causing a post-operative infection.
A specific bacterium called Staphylococcus aureus (S. aureus) is the most common pathogen targeted by this nasal preparation. Approximately 20% to 30% of the human population carry S. aureus in their nose without showing symptoms, making them “carriers.” Colonization with S. aureus significantly increases a patient’s risk for developing an SSI caused by this organism.
The nasal application of an antiseptic is a targeted “decolonization” strategy intended to eliminate this bacterial reservoir before the surgical procedure begins. This is particularly important because S. aureus includes strains like MRSA (methicillin-resistant S. aureus), which are resistant to many common antibiotics. By reducing the bacterial load in the nose, healthcare providers reduce the overall risk of these microbes contaminating the surgical wound.
How Iodine Works and What to Expect
The antiseptic solution used for this pre-surgical nasal preparation is most commonly Povidone-Iodine (PVP-I), which is often referred to simply as iodine. Unlike antibiotics, PVP-I is an antiseptic that has a broad-spectrum action against bacteria, viruses, and fungi. Povidone-Iodine rapidly kills microbes by releasing free iodine, which quickly penetrates the bacterial cell wall and disrupts the structure of proteins and fatty acids within the cell.
The application is a simple and quick procedure performed by a nurse or other healthcare professional, typically within an hour or two before the surgery. The solution is generally a 5% PVP-I formulation, which is applied using a swab or cotton-tipped applicator that is rotated inside each nostril for a short period, often around 30 seconds per side. Patients may experience a slight smell or taste, or a minor, temporary stinging sensation, but the process is generally well-tolerated.
After the application, patients are usually instructed not to blow or wipe their nose for a while to allow the antiseptic to remain in contact with the nasal lining and maximize its effect. Patients are screened for any known sensitivity to iodine-based products before use. This single, brief application provides a rapid and effective method of decolonization, serving as a crucial component of modern infection control practices.

